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Background: Nepal's low fertility rate and increasing life expectancy have resulted in a burgeoning older population. For millennia, filial piety shaped family cohesion and helped Nepali older adults achieve positive outcomes, but recently, it has been eroding. Furthermore, there are not enough institutional support options or alternatives to family-based care to deal with the biosocial needs of older adults. This study explored the association between family support and self-rated health among Nepali older adults.
Methods: A community-based cross-sectional survey in eastern Nepal's two districts, Sunsari and Morang, interviewed 847 older adults (≥ 60 years). The final analytical sample was 844. Participants were asked whether they received assistance with various aspects of daily life and activities of daily living from their families. Multivariable logistic regression examined the association between family support and self-rated health.
Results: Participants who received support with various aspects of daily life had 43% higher odds of good health, but after adjusting for control variables, the result only approached statistical significance (p = 0.087). Those who received family assistance with activities of daily living had nearly four times higher odds (OR: 3.93; 95% CI: 2.58 - 5.98) of reporting good health than participants who lacked this support.
Conclusions: Given the important role of family support in Nepali older adults' health, government programs and policies should create a conducive environment to foster family-based care until more comprehensive policies for older adults' care can be put into effect. The results of this study can also help shape the global aging environment by highlighting the need for family support in older care, particularly in low-income nations with declining traditional care systems and weak social security policies.
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http://dx.doi.org/10.1186/s12877-023-04619-1 | DOI Listing |
Nutr Clin Pract
September 2025
Department of Pediatrics, Mayo Clinic, Rochester, Minnesota, USA.
Home parenteral nutrition (HPN) is a life-sustaining therapy traditionally used as a bridge to enteral autonomy or intestinal transplantation. Increasingly, it is used for intractable feeding intolerance (IFI), which can occur near the end of life (EOL) in children with severe neurological impairment (SNI). In these cases, HPN use differs from its historical role and requires tailored outpatient planning.
View Article and Find Full Text PDFJ Affect Disord
September 2025
School of Public Health, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong; The State Key Laboratory of Brain and Cognitive Sciences, The University of Hong Kong, Hong Kong; Urban Systems Institute, The University of Hong Kong, Hong Kong. Electronic address:
Background: Globally, childhood neglect remains common in both developed and developing settings. However, there is a lack of robust evidence regarding the association between childhood neglect and adult mental disorders.
Methods: Using a sibling-comparison study nested within the FAMILY Cohort, we assessed the role of childhood neglect and abuse in adult mental disorders, taking into account known and unknown familial confounders shared by siblings.
Acad Pediatr
September 2025
Department of Pediatrics, University of Minnesota, Minneapolis, MN.
Safe and stable housing is foundational for child and adolescent health; likewise, housing instability and homelessness are associated with significant pediatric health risk. This narrative review sought to: (1) describe the impact of stable housing, housing instability, and homelessness on child and adolescent health, and (2) explore advocacy interventions for pediatricians to support unstably housed children, youth and families. While the relationship between health and housing is complex, here, we describe three primary mechanisms through which housing impacts pediatric health.
View Article and Find Full Text PDFInt J Biol Macromol
September 2025
Department of Biomedical Science, Acharya Narendra Dev College, University of Delhi, Govindpuri, Kalkaji, 110019, New Delhi, India. Electronic address:
Mycobacteriophage-encoded LysinB enzymes target mycolyl ester linkages in mycolyl-arabinogalactan-peptidoglycan of mycobacterium hosts and generally exhibit a globular architecture. Here, we present the structural and functional characterization of a novel Mycobacterium fortuitum prophage-encoded modular LysinB (LysinB_MF), which contains the α/β hydrolase domain and a distinct peptidoglycan-binding domain (PGBD). The enzyme's active site features the conserved Ser-Asp-His catalytic triad common to esterases and forms a funnel-like topology.
View Article and Find Full Text PDFPatient Educ Couns
August 2025
Division of Oncology, Stanford University School of Medicine, Stanford, CA, USA.
Objective: To examine how communication needs regarding prognosis, treatment options, and palliative care evolve over time for patients with advanced cancer and their family caregivers, particularly as patients approach the end-of-life.
Methods: This mixed-methods study surveyed 272 patients at a California healthcare system from October 2019-November 2021 at 1, 4, 8, and 12 months after identification of advanced cancer. Additionally, 24 family caregivers were interviewed between March 2021-May 2022.