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http://dx.doi.org/10.1136/bjsports-2023-106749 | DOI Listing |
Int J Sports Physiol Perform
July 2025
Department of Exercise and Sport Science, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Background: Recent research findings suggest that a daily diet containing low carbohydrate (LCHO) consumption coupled with low energy availability (LEA, specifically what is termed problematic LEA [P-LEA]) exacerbates the risk of developing relative energy deficiency in sport (REDs). Regrettably, research evidence also indicates that dietary carbohydrates are likely underconsumed by many athletes in their daily diets. How these factors, P-LEA and LCHO intake, interact to precipitate the amplification of REDs risk is currently not entirely clear and is the source of much speculation.
View Article and Find Full Text PDFOsteoarthritis Cartilage
September 2025
Department of Joint and Orthopedics, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China. Electronic address:
Objective: Tamoxifen (TAM) has been used to treat human breast cancer and induce gene knockout in the Cre/loxP system in mice. However, the effects of TAM as a CreER recombinase inducer on bone metabolism, cartilage metabolism, and endochondral ossification have not been thoroughly evaluated.
Methods: Mice received 5 intraperitoneal TAM injections in the trauma and age-induced osteoarthritis (OA) model and the fracture model.
Nutrients
May 2025
Department of Child Neuropsychiatry, Fondazione IRCCS San Gerardo dei Tintori, 20900 Monza, Italy.
: Individuals with inflammatory bowel diseases (IBDs) have an increased risk of developing psychiatric co-morbidities, including restrictive eating disorders (REDs), with which they share common pathogenic mechanisms, including gut-brain axis dysregulation. We conducted a case-control study systematically exploring the psychopathological profiles and alexithymia in adolescents with IBDs compared with a clinical group of adolescents diagnosed with REDs in order to test the hypothesis of common psychological characteristics between the two patient populations. : We recruited 76 patients with IBDs and 76 age-matched controls with REDs (64 adolescents with anorexia nervosa and 12 adolescents with avoidant/restrictive food intake disorder).
View Article and Find Full Text PDFInt J Eat Disord
April 2025
Department of Psychiatry, University of California San Diego Health, San Diego, California, USA.
Objective: Outcomes for low-weight restrictive eating disorders, including anorexia nervosa, restricting type (AN-R) and avoidant/restrictive food intake disorder (ARFID), are sub-optimal. Reducing dietary restriction is a key treatment target. Understanding heterogeneity in patterns of change in dietary restriction may aid in improving outcomes.
View Article and Find Full Text PDFBio Protoc
December 2024
Division of Life Science, Graduate School of Science and Engineering, Saitama University, Shimo-Okubo 255, Sakura-ku, Saitama, Japan.
Zebrafish and medaka are valuable model vertebrates for genetic studies. The advent of CRISPR-Cas9 technology has greatly enhanced our capability to produce specific gene mutants in zebrafish and medaka. Analyzing the phenotypes of these mutants is essential for elucidating gene function, though such analyses often yield unexpected results.
View Article and Find Full Text PDF