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Background: Many modern e-cigarette brands contain equivalent or higher nicotine levels than traditional cigarettes.
Objective: To examine differences in four nicotine dependence indicators (i.e., use within 30minutes of waking, cravings, needing to use, and frequent use) among adolescents (aged 12-17 years) with past 30-day (P30D) exclusive use of e-cigarettes, cigarettes, or dual use of both.
Methods: Data were from Wave 5 (2018-2019) of the Population Assessment of Tobacco and Health (PATH) study (n=1060; N=2053,659). Multivariable logistic regression was performed to determine differences in indicators by P30D e-cigarette and cigarette use behavior (exclusive vs. dual use) and brand (e-cigarette use: JUUL vs. non-JUUL vs. Unknown).
Results: The odds of frequent use among adolescents with JUUL (AOR: 2.11; 95% CI=1.02-4.37) and non-JUUL (AOR: 2.12; 95% CI=0.95-4.77) use were similar and paralleled that for dual use (AOR: 3.50; 95% CI=1.46-8.43) but were stronger (JUUL only) than exclusive cigarette use. The odds of using within 30minutes of waking for adolescents with JUUL (AOR: 2.23; 95% CI=0.80-6.25) and non-JUUL (AOR:1.42; 95% CI=0.47-4.32) use were similar and paralleled that for both dual (AOR=3.00; 95% CI=1.01-8.88) and exclusive cigarette use. For adolescents who used unknown brands, the odds of all indicators paralleled exclusive cigarette use but were lower than JUUL, non-JUUL, and dual use.
Conclusion: Compared to exclusive cigarette use, symptoms of nicotine dependence are similar for adolescents with exclusive e-cigarette use, irrespective of brand. Symptoms of nicotine dependence for JUUL and non-JUUL use parallel dual use. Tobacco regulation should consider these findings when assessing the abuse liability of e-cigarettes.
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http://dx.doi.org/10.1016/j.drugalcdep.2023.111059 | DOI Listing |
Cureus
August 2025
Public Health, High Institute of Public Health, Alexandria University, Alexandria, EGY.
Background: Smoking cigarettes is increasingly becoming a strong focus of concern for public health in Saudi Arabia, especially with the rise in mental health disorders. This research explores how depression, anxiety, and stress are related to the level of dependence on nicotine.
Methods: This cross-sectional study involved 310 adult smokers and utilized face-to-face interviews to collect data on participants' sociodemographic and lifestyle factors, nicotine dependence through the Fagerstrom Test of Nicotine Dependence (FTND), and mental health status using a validated Arabic version of the short form of the Depression Anxiety Stress Scales (DASS-21).
Tob Induc Dis
September 2025
Department of Family and Community Medicine, Faculty of Medicine, University of Jeddah, Jeddah, Saudi Arabia.
Introduction: Tobacco smoking continues to pose a major global public health challenge. Medical students play a crucial role in shaping future smoking cessation practices. Nicotine pouches have recently emerged as a tobacco-free alternative with a potentially reduced harm profile.
View Article and Find Full Text PDFBMJ Open
September 2025
Centre for Non-communicable Diseases and Nutrition, BRAC University James P Grant School of Public Health, Dhaka, Bangladesh
Objective: The rising burden of non-communicable diseases (NCDs), including mental health disorders (MHDs) such as anxiety and depression, poses a significant public health challenge globally. Evidence suggests that both diabetes and hypertension, the two most prevalent NCDs, are linked to a higher prevalence of MHDs. However, there is a lack of evidence on prevalence of generalised anxiety disorder (GAD) and depression among adults living with both diabetes and hypertension in Bangladesh.
View Article and Find Full Text PDFJ Am Acad Orthop Surg
August 2025
From the Department of Medical Education, Texas A&M College of Medicine, Dallas, TX (Sontam, Toussaint, Hlavinka, Chavda, and Mbilinyi), and the Department of Orthopedic Surgery, Baylor University Medical Center, Dallas, TX (Zide).
Background: Smoking is a well-established risk factor for postoperative complications following open reduction and internal fixation (ORIF) for rotational ankle fractures. However, the effect of non-tobacco nicotine (NTN) use on these outcomes remains unclear, despite the increasing use of products such as vapes. This retrospective cohort study investigates whether perioperative NTN use is associated with increased postoperative complications following ankle ORIF compared with a nicotine-independent (NI) control group.
View Article and Find Full Text PDFFunctional magnetic resonance imaging (fMRI) is central to studying neurobiological mechanisms, yet fMRI has limited clinical utility, highlighting the need for novel approaches. We show that a component of the fMRI signal-the systemic low-frequency oscillation (sLFO), linked to blood flow and physiological measures of arousal-indexes trait- and state-level drug use phenotypes. In individuals who chronically use nicotine, sLFO amplitude increased during abstinence and correlated with heightened dependence severity and cue-induced craving.
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