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Article Abstract
A bioinspired design built around a neutral flavin-triphenylamine core has been investigated for selective mitochondrial bioimaging capabilities in different microenvironments. Significant advantages with respect to long-term tracking, faster internalization, penetrability within the spheroid structures, and strong emission signal under induced hypoxia conditions have been observed, which could offer an alternative to the existing mitotrackers for hypoxia-related biological events.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10726442 | PMC |
| http://dx.doi.org/10.1021/acsmedchemlett.3c00446 | DOI Listing |
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A Neutral Flavin-Triphenylamine Probe for Mitochondrial Bioimaging under Different Microenvironments.
ACS Med Chem Lett
December 2023
Department of Chemistry, Indian Institute of Technology, Sangareddy, Hyderabad 502285, Telangana, India.
A bioinspired design built around a neutral flavin-triphenylamine core has been investigated for selective mitochondrial bioimaging capabilities in different microenvironments. Significant advantages with respect to long-term tracking, faster internalization, penetrability within the spheroid structures, and strong emission signal under induced hypoxia conditions have been observed, which could offer an alternative to the existing mitotrackers for hypoxia-related biological events.
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