Ligand Promoted Pd-Catalyzed High -Selective C-H Olefination.

Org Lett

State Key Laboratory of Materials-Oriented Chemical Engineering, School of Pharmaceutical Sciences, Nanjing Tech University, Nanjing 210009, China.

Published: December 2023


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Article Abstract

Achieving high -selective C-H functionalized products of benzoic acid derivatives using a designed template is still a daunting challenge because the carbonyl group also could coordinate with metal to activate the -C-H bond. Herein, we report the ligand promoted high -selective C-H olefination of benzoic acid derivatives; we screened a series of ligands increasing the ratio of :others from 62:38 to 96:4. This work may find application in the construction of -substituted benzoic acid derivatives.

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http://dx.doi.org/10.1021/acs.orglett.3c03201DOI Listing

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