98%
921
2 minutes
20
Introduction: Mapping of the human genome, together with the broad understanding of new biomolecular pathways involved in cancer development, represents a huge dividing line for advances in cancer treatment. This special article aims to express the next evolution of cancer therapy, while also considering the challenges and uncertainties facing future directions.
Area Covered: The recent achievements of medical science in the oncology field concern both new diagnostic techniques, such as liquid biopsy, and therapeutic strategies with innovative anticancer drugs. Although several molecular characteristics of tumors are linked to the tissue of origin, some mutations are shared by multiple tumor histologies, thus paving the way for what is called 'precision oncology.' The article highlights the importance of identifying new mutations and biomolecular pathways that can be pursued with new anticancer drugs.
Expert Opinion: Oncology and medical science have made great progress in understanding new molecular targets; being able to early identify tumor markers that are not confined to a single organ through minimally invasive diagnostic techniques allows us to design new effective therapeutic strategies. Multidisciplinary teams now aim to evaluate the most appropriate and personalized diagnostic/therapeutic approach for the individual patient.
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.1080/14728222.2023.2295493 | DOI Listing |
Adv Mater
September 2025
KU-KIST Graduate School of Converging Science and Technology, Korea University, 145 Anam-ro, Seongbuk-gu, Seoul, 02841, Republic of Korea.
Metal-nitrogen-carbon (M-N-C) catalysts display considerable potential as cost-effective alternatives to noble metals in oxygen electrocatalysis. However, uncontrolled atomic migration and random structural rearrangement during pyrolysis often lead to disordered coordination environments and sparse active sites, fundamentally limiting their intrinsic catalytic activities and long-term durability. Herein, a novel strategy is reported for use in directionally regulating atomic migration pathways via the incorporation of a foreign metal (La).
View Article and Find Full Text PDFFront Plant Sci
August 2025
Plant Protection and Biomolecular Diagnosis Department, Arid Lands Cultivation Research Institute, City of Scientific Research and Technological Applications, Alexandria, Egypt.
The utilization of arbuscular mycorrhizal fungi (AMF) and spp. correlates with improved plant nutrition and the stimulation of systemic plant defenses in response to pathogen challenges. Nonetheless, studies examining the effects of AMF colonization and the foliar application of the isolate Tvd44 on viral infection are limited.
View Article and Find Full Text PDFFront Pharmacol
August 2025
Department of Clinical Immunology and Rheumatology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.
Peritoneal Dialysis (PD) requires a healthy and functional peritoneal membrane for adequate ultrafiltration and fluid balance, making it a vital treatment for patients with end-stage renal disease (ESRD). The spectrum of PD-associated peritoneal fibrosis encompasses a diverse range of collective mechanisms: peritoneal fibrogenesis, epithelial to mesenchymal transition (EMT), peritonitis, angiogenesis, sub-mesothelial immune cells infiltration, and collagen deposition in the sub-mesothelial compact zone of the membrane that accompany deteriorating membrane function. In this narrative review, we summarize the repertoire of current knowledge about the structure, function, and pathophysiology of the peritoneal membrane, focusing on biomolecular mechanisms and signalling pathways that potentiate the development and progression of peritoneal fibrosis.
View Article and Find Full Text PDFInsect Biochem Mol Biol
September 2025
Laboratory of Molecular Entomology and Bee Pathology (L-MEB), Department of Biochemistry and Microbiology, Faculty of Sciences, Ghent University, Ghent, Belgium. Electronic address:
This study maps the surfaceome of Apis mellifera hemocytes, the protagonist cells in honey bee cellular immunity. The surfaceome, proteins expressed at the cell surface, is crucial as it determines how cells interact with their microenvironment. Through a combination of proteomic and transcriptomic analyses, 1142 genes encoding cell surface proteins were identified, revealing a high level of diversity.
View Article and Find Full Text PDFMol Cell
August 2025
Lingang Laboratory, Shanghai 200031, China. Electronic address:
YAP/TAZ are transcriptional co-activators that pair with transcription factor TEA/ATTS domains (TEADs) for modulating the Hippo pathway. Previous works propose the potential role of YAP/TAZ phase separation for transcriptional activation, yet the biomolecular basis of endogenous YAP/TAZ-TEAD condensates remains unclear. Here, we dissect their endogenous morphology, revealing that YAP/TAZ are client proteins recruited to TEAD condensates in various human cell lines.
View Article and Find Full Text PDF