98%
921
2 minutes
20
Download full-text PDF |
Source |
---|---|
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10713290 | PMC |
http://dx.doi.org/10.21037/jtd-23-1483 | DOI Listing |
Ann Hematol
September 2025
Hematology and Transplant Center, University Hospital"San Giovanni di Dio e Ruggi d'Aragona", Salerno, Italy.
Functional high risk multiple myeloma (FHRMM) remains a challenging entity with poor outcomes and limited survival, and there is no international consensus on optimal second-line therapeutic strategies in relapsed/refractory patients. In this multicenter real-world retrospective study, we investigated clinical characteristics and outcomes of a total of 62 FHRMM patients previously treated with a first-line daratumumab-based quadruplet regimen or who relapsed within 12 months after frontline autologous stem cell transplantation (ASCT). In our cohort, the overall response rate was 61%, with 42% of patients achieving a very good partial response (VGPR) or better.
View Article and Find Full Text PDFDev Cell
September 2025
Department of Pharmacology, University of Cambridge, Cambridge, UK; Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK. Electronic address:
Single-cell studies on breast tissue have contributed to a change in our understanding of breast epithelial diversity that has, in turn, precipitated a lack of consensus on breast cell types. The confusion surrounding this issue highlights a possible challenge for advancing breast atlas efforts. In this perspective, we present our consensus on the identities, properties, and naming conventions for breast epithelial cell types and propose goals for future atlas endeavors.
View Article and Find Full Text PDFWater Res
September 2025
College of Hydrology and Water Resources, Hohai University, Nanjing 210098, China. Electronic address:
Groundwater overextraction presents persistent challenges due to strategic interdependence among decentralized users. While game-theoretic models have advanced the analysis of individual incentives and collective outcomes, most frameworks assume fully rational agents and neglect the role of cognitive and social factors. This study proposes a coupled model that integrates opinion dynamics with a differential game of groundwater extraction, capturing the interaction between institutional authority and evolving stakeholder preferences.
View Article and Find Full Text PDFRetina
September 2025
Department of Ophthalmology, Inselspital, Bern University Hospital, University of Bern, Freiburgstrasse 15, CH-3010.
Purpose: To evaluate inter-grader variability in posterior vitreous detachment (PVD) classification in patients with epiretinal membrane (ERM) and macular hole (MH) on spectral-domain optical coherence tomography (SD-OCT) and identify challenges in defining a reliable ground truth for artificial intelligence (AI)-based tools.
Methods: A total of 437 horizontal SD-OCT B-scans were retrospectively selected and independently annotated by six experienced ophthalmologists adopting four categories: 'full PVD', 'partial PVD', 'no PVD', and 'ungradable'. Inter-grader agreement was assessed using pairwise Cohen's kappa scores.
Eur Spine J
September 2025
Hong Kong Polytechnic University, Hong Kong, China.
Purpose: The purpose of this study was to determine through a Delphi process a list of outcomes measures for clinicians to use when assessing individuals with Lumbar Spinal Stenosis (LSS).
Methods: A three-phase Delphi process was conducted by the International Society for the Study of the Lumbar Spine (ISSLS) Lumbar Spinal Stenosis Taskforce, including two online surveys, two virtual meetings, and three in-person consensus meetings at the ISSLS annual conferences (2023-2025). Participants evaluated and ranked outcome measures for LSS, with final endorsement requiring > 66% agreement.