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Article Abstract
This study, utilizing SBF-SEM, reveals structural alterations in mitochondria and myofibrils in human heart failure (HF). Mitochondria in HF show changes in structure, while myofibrils exhibit increased cross-sectional area and branching. Metabolomic and lipidomic analyses indicate concomitant dysregulation in key pathways. The findings underscore the need for personalized treatments considering individualized structural changes in HF.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10705476 | PMC |
| http://dx.doi.org/10.1101/2023.11.28.569095 | DOI Listing |
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