Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Cabozantinib malate (CBZM), a new anticancer medication, has been studied for its solubility and thermodynamic properties in a variety of {dimethyl sulfoxide (DMSO) + water (HO)} mixtures at 298.2-318.2 K and 101.1 kPa. Using the shake flask technique, the solubility of CBZM was assessed and the results were correlated to the van't Hoff, Apelblat, Buchowski-Ksiazczak , Yalkowsky-Roseman, Jouyban-Acree, and Jouyban-Acree-van't Hoff models. There was a significant correlation between the experimental CBZM solubility data and all computational models, as evidenced by the error values for all computational models being less than 5.0%. Temperature and DMSO mass percentage improved the CBZM mole fraction solubility in the cosolvent solutions of {DMSO + HO}. At 318.2 K, pure DMSO had the highest mole fraction solubility of CBZM (4.38 × 10), whereas pure HO had the lowest mole fraction solubility (2.24 × 10 at 298.2 K). The positive values of computed thermodynamic parameters indicated that the dissolution of CBZM was endothermic and entropy-driven in all of the {DMSO + HO} solutions investigated. It was found that the CBZM solvation in {DMSO + HO} solutions is governed by enthalpy. When compared to CBZM-HO, CBZM-DMSO showed the highest molecular interactions. The findings of this investigation demonstrated that DMSO has a great deal of potential for CBZM solubilization in HO.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10707982 | PMC |
| http://dx.doi.org/10.3390/molecules28237805 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Quantifying the mixing behavior of direct injected hydrogen in high-pressure environments by Rayleigh scattering.
Appl Phys B
September 2025
Department of Mechanical Engineering, Eindhoven University of Technology, P.O. Box 513, 5600 MB Eindhoven, The Netherlands.
Unlabelled: In the framework of the Argon Power Cycle, millisecond-pulsed hydrogen gas injections into a high-pressure, room temperature nitrogen or argon ambient are investigated. Instantaneous Rayleigh scattering is used to quantify the hydrogen mole fraction in the ensuing jets. A readily available HDEV injector with a straight 0.
View Article and Find Full Text PDFRapid Copolymer Analysis of Unresolved Mass Spectra by Artificial Intelligence.
Anal Chem
September 2025
Department of Applied Chemistry, Faculty of Science and Technology, University of Debrecen, Egyetem tér 1, H-4032 Debrecen, Hungary.
In this Article, we present a novel data analysis method for the determination of copolymer composition from low-resolution mass spectra, such as those recorded in the linear mode of time-of-flight (TOF) mass analyzers. Our approach significantly extends the accessible molecular weight range, enabling reliable copolymer composition analysis even in the higher mass regions. At low resolution, the overlapping mass peaks in the higher mass range hinder a comprehensive characterization of the copolymers.
View Article and Find Full Text PDFBinary Mixtures of Ionic Liquids to Enhance Dicationic Ionic Liquid Performance: Insights from Molecular Dynamics Simulations and Quantum Mechanics.
J Phys Chem B
August 2025
Department of Chemistry, University of Isfahan, Isfahan 81746-73441, Iran.
In this work, the effect of adding a monocationic ionic liquid (MIL) on the properties of a dicationic ionic liquid (DIL) was investigated using molecular dynamics (MD) simulations and quantum mechanical (QM) calculations. The binary mixture of [C(mim)][NTf] (DIL) and [PEOE][NTf] (MIL) was analyzed in terms of thermophysical, structural, and dynamical properties, along with density functional theory (DFT) and atoms-in-molecules (AIM) analyses. These properties were compared to those of the pure DIL system.
View Article and Find Full Text PDFDual modulation of the anion-driven thermodynamic properties of aqueous choline halide-based deep eutectic solvents.
J Chem Phys
August 2025
Department of Chemistry, Case Western Reserve University, Cleveland, Ohio 44106, USA.
Deep eutectic solvents (DESs) are considered tunable solvents because their specific properties can be achieved based on the choice of components and their relative concentrations in a mixture. In this work, we investigate the influence of the variation in halide ions (F-, Cl-, Br-, I-) of choline salts used on the thermodynamic and physicochemical properties of choline halide-based DESs. Our findings show that the density of choline halide-based DESs decreases nonlinearly with an increasing mole fraction of water, following a trend based on the size of the halides, with choline iodide showing the highest density.
View Article and Find Full Text PDFSolution Thermodynamics of Methyl, Ethyl, Propyl, and Butyl Lactates in High-Pressure CO.
ACS Omega
August 2025
Department of Chemical and Biomolecular Engineering, Chonnam National University, Yeosu, Jeonnam 59626, South Korea.
The demand for alkyl lactates (methyl, ethyl, propyl, and butyl) has risen significantly due to their unique properties and wide industrial applications. Accurate vapor-liquid equilibrium data are vital for the design and optimization of separation techniques involving these compounds, particularly in systems using supercritical carbon dioxide (SC-CO) as a solvent. In this study, the phase transition of binary systems of CO + lactate (methyl, ethyl, propyl, butyl) was investigated at various temperatures (313.
View Article and Find Full Text PDF