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Objectives: To evaluate the subtle peripheral retinal and macular vascular changes in the fellow eyes of patients with unilateral retinal vein occlusion (RVO).
Materials And Methods: This retrospective study included 53 patients with unilateral RVO and 44 age-matched controls. The frequency of peripheral retinal vascular pathologies in both eyes was evaluated using high quality ultra-wide field fluorescein angiography (UWFFA). Macular vascular density, flow area, and foveal avascular zone measurements from optical coherence tomography angiography (OCTA) were analyzed together with laser flare photometry values in patients and controls.
Results: Peripheral retinal vascular pathologies were detected on UWFFA in the fellow eyes of 36 (67.9%) patients. No significant central vascular pathologies were detected on OCTA and there was no significant difference in OCTA parameters between the fellow eyes and the controls. Flare values did not differ significantly between the control and the fellow eyes.
Conclusion: Two thirds of the fellow eyes of unilateral RVO patients had subtle peripheral retinal vascular changes, while there was no significant microvascular change detected with OCTA in the macula. This suggests that vascular changes caused by systemic vascular disorders probably first start in the peripheral retina of the fellow eyes of patients with RVO.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10750094 | PMC |
http://dx.doi.org/10.4274/tjo.galenos.2023.94389 | DOI Listing |
Transl Vis Sci Technol
September 2025
Department of Ophthalmology, University of Pittsburgh, School of Medicine, Pittsburgh, Pennsylvania, USA.
Purpose: To evaluate choroidal vasculature using a novel three-dimensional algorithm in fellow eyes of patients with unilateral chronic central serous chorioretinopathy (cCSC).
Methods: Patients with unilateral cCSC were retrospectively included. Automated choroidal segmentation was conducted using a deep-learning ResUNet model.
Oral Oncol
September 2025
Center for Surgery and Public Health, Department of Surgery, Brigham and Women's Hospital, Boston, MA, USA; Department of Otolaryngology-Head and Neck Surgery, Harvard Medical School, Division of Otolaryngology-Head and Neck Surgery, Brigham and Women's Hospital; Center for Head and Neck Oncology, D
Introduction: Delays in head and neck cancer (HNC) diagnosis and treatment and financial burdens of care are often rooted in social determinants of health (SDOH), such as financial instability, socioeconomic status (SES), health insurance status, and transportation barriers. While these factors are well recognized, their underlying impact on access to care remains underexplored; this qualitative study aims to investigate how these SDOH facilitate or hinder HNC care through insights from patients and healthcare workers (HCWs) in the United States, to identify targets for intervention.
Methods: Semi-structured interviews were conducted with patients with newly diagnosed HNC, and HCWs caring for these patients, between June 2022 and July 2023.
Transl Vis Sci Technol
September 2025
State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou, China.
Purpose: To investigate the spatial relationship between choroidal vortex veins (VVs), choroidal watershed zones (CWZs), and polypoidal lesion distribution in different subtypes of polypoidal choroidal vasculopathy (PCV) categorized by choroidal vascular hyperpermeability (CVH) status.
Methods: This retrospective study analyzed 58 treatment-naïve PCV eyes using widefield imaging to map dominant VVs, CWZs, and lesion locations. Eyes were stratified into CVH (n = 32) and non-CVH (n = 26) groups.
Invest Ophthalmol Vis Sci
September 2025
Department of Ophthalmology, University of California, Los Angeles, Los Angeles, California, United States.
Purpose: Simulations suggest that displacement of rectus extraocular muscle pulleys in superior oblique (SO) palsy accounts for incomitant strabismus patterns even without postulating SO contractile weakness. We asked how rectus extraocular muscle pulleys reorient during head tilt in SO palsy.
Methods: In 13 subjects with unilateral SO palsy, supine magnetic resonance imaging (MRI) in 2-mm-thick quasi-coronal planes in target-controlled central gaze was repeated in both lateral decubitus positions equivalent to 90° head tilts.
Retina
August 2025
Department of Ophthalmology, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan.
Purpose: This study aimed to investigate changes in choroidal thickness using widefield optical coherence tomography following anti-vascular endothelial growth factor (VEGF) therapy for neovascular age-related macular degeneration (AMD).
Methods: We examined 69 patients with unilateral neovascular AMD. All patients underwent three monthly intravitreal injections of anti-VEGF agents.