Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Desmoid tumors (DTs), also called desmoid-type fibromatoses, are locally aggressive tumors of mesenchymal origin. In the present study, we developed a novel mouse model of DTs by inducing a local mutation in the Ctnnb1 gene, encoding β-catenin in PDGFRA-positive stromal cells, by subcutaneous injection of 4-hydroxy-tamoxifen. Tumors in this model resembled histologically clinical samples from DT patients and showed strong phosphorylation of nuclear SMAD2. Knockout of SMAD4 in the model significantly suppressed tumor growth. Proteomic analysis revealed that SMAD4 knockout reduced the level of Cysteine-and-Glycine-Rich Protein 2 (CSRP2) in DTs, and treatment of DT-derived cells with a TGF-β receptor inhibitor reduced CSRP2 RNA levels. Knockdown of CSRP2 in DT cells significantly suppressed their proliferation. These results indicate that the TGF-β/CSRP2 axis is a potential therapeutic target for DTs downstream of TGF-β signaling.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10859603 | PMC |
| http://dx.doi.org/10.1111/cas.16037 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Targeting the gut-liver axis with dietary polyphenols to ameliorate metabolic dysfunction-associated steatotic liver disease: advances in molecular mechanisms.
Crit Rev Food Sci Nutr
September 2025
Hunan Key Laboratory of Deep Processing and Quality Control of Cereals and Oils, State Key Laboratory of Utilization of Woody Oil Resource, College of Food Science and Engineering, Central South University of Forestry and Technology, Changsha, Hunan, China.
Metabolic dysfunction-associated steatotic liver disease (MASLD) is a condition that results from metabolic disorders. In addition to genetic factors, irregular and high-energy diets may also significantly contribute to its pathogenesis. Dietary habits can profoundly alter the composition of gut microbiota and metabolites.
View Article and Find Full Text PDFState-Dependent Dynamic Communication Networks in a Pentameric Ligand-Gated Ion Channel.
J Phys Chem B
September 2025
School of Science, RMIT University, Melbourne 3000, Australia.
Pentameric ligand-gated ion channels control synaptic neurotransmission via an allosteric mechanism, whereby agonist binding induces global protein conformational changes that open an ion-conducting pore. For the proton-activated bacterial () ligand-gated ion channel (GLIC), high-resolution structures are available in multiple conformational states. We used a library of atomistic molecular dynamics (MD) simulations to study conformational changes and to perform dynamic network analysis to elucidate the communication pathways underlying the gating process.
View Article and Find Full Text PDFAge-related evolution of serum biochemistry and intestinal fatty acid signaling, innate immune response and barrier function in suckling and newly weaned piglets.
J Anim Sci
September 2025
Centre for Veterinary Systems Transformation and Sustainability, Clinical Department for Farm Animals and Food System Science, University of Veterinary Medicine Vienna, Vienna 1210, Austria.
It is helpful for diagnostic purposes to improve our current knowledge of gut development and serum biochemistry in young piglets. This study investigated serum biochemistry, and gut site-specific patterns of short-chain fatty acids (SCFA) and expression of genes related to barrier function, innate immune response, antioxidative status and sensing of fatty and bile acids in suckling and newly weaned piglets. The experiment consisted of two replicate batches with 10 litters each.
View Article and Find Full Text PDFCellulose Acetate Nanofiber and Sodium Alginate-Based Conductive Aerogel for Human Motion Monitoring.
Macromol Rapid Commun
September 2025
School of Materials and Chemistry, Anhui Agricultural University, Hefei, Anhui, China.
At present, flexible sensors are a hot spot in research and experimental development, but the research on flexible sensors that can be used for human motion monitoring still needs to be deepened. In this work, the green material cellulose acetate (CA) was used as the matrix material, the film was made by electrospinning, crushed by a cell grinder and sodium alginate (SA) was added to promote the uniform dispersion of nanofibers in water, and then methyltrimethoxysilane (MTMS) and MXene nanosheet dispersion were added to make it hydrophobic and good conductivity, and the aerogel precursor solution was prepared, and then the CA/SA/MTMS/MXene aerogel with directional holes was prepared by directional freeze-drying. As a flexible sensor material, it can be used for human wear, monitoring the electrical signals generated by the movement of human joints and other parts, and can still maintain a current of about 0.
View Article and Find Full Text PDFAn Antibacterial and Electroactive Chitosan-Based Dressing with Dual Stimulus-Responsive Drug Delivery for Wound Healing.
Macromol Rapid Commun
September 2025
Key Laboratory of Textile Science & Technology, College of Textiles, Ministry of Education, Donghua University, Shanghai, China.
Persistent bacterial infections remain a major challenge in wound management. Although drug-loaded wound dressings have gained increasing attention, their therapeutic efficacy is often hindered by uncontrolled drug release and a lack of electrical signal responsiveness. Herein, an antibacterial dressing (CCS-PC) with electroactivity and stimulus-responsive drug release properties was fabricated via electro-assembly, wherein chitosan and ciprofloxacin hydrochloride (CIP) were co-deposited onto polypyrrole (PPy)-coated gauze.
View Article and Find Full Text PDF