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Currently, in most traditional VSLAM (visual SLAM) systems, static assumptions result in a low accuracy in dynamic environments, or result in a new and higher level of accuracy but at the cost of sacrificing the real-time property. In highly dynamic scenes, balancing a high accuracy and a low computational cost has become a pivotal requirement for VSLAM systems. This paper proposes a new VSLAM system, balancing the competitive demands between positioning accuracy and computational complexity and thereby further improving the overall system properties. From the perspective of accuracy, the system applies an improved lightweight target detection network to quickly detect dynamic feature points while extracting feature points at the front end of the system, and only feature points of static targets are applied for frame matching. Meanwhile, the attention mechanism is integrated into the target detection network to continuously and accurately capture dynamic factors to cope with more complex dynamic environments. From the perspective of computational expense, the lightweight network Ghostnet module is applied as the backbone network of the target detection network YOLOv5s, significantly reducing the number of model parameters and improving the overall inference speed of the algorithm. Experimental results on the TUM dynamic dataset indicate that in contrast with the ORB-SLAM3 system, the pose estimation accuracy of the system improved by 84.04%. In contrast with dynamic SLAM systems such as DS-SLAM and DVO SLAM, the system has a significantly improved positioning accuracy. In contrast with other VSLAM algorithms based on deep learning, the system has superior real-time properties while maintaining a similar accuracy index.
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http://dx.doi.org/10.3390/s23229274 | DOI Listing |
Esophagus
September 2025
Department of Surgery, Tohoku University Graduate School of Medicine, 1-1 Seiryo-Machi, Aoba-Ku, Sendai, Miyagi, Japan.
Background: The cluster of differentiation 47 (CD47)-signal regulatory protein alpha (SIRPα) axis is a key regulator of innate immune surveillance, facilitating the neoplastic evasion of macrophage-mediated phagocytosis. Although this pathway has been implicated in tumor immune escape in multiple malignancies, its clinical and prognostic significance in esophageal squamous cell carcinoma (ESCC) remain to be fully elucidated.
Methods: We retrospectively analyzed 100 patients who underwent esophagectomy for resectable ESCC.
Nat Aging
September 2025
Aging Biomarker Consortium (ABC), Beijing, China.
The global surge in the population of people 60 years and older, including that in China, challenges healthcare systems with rising age-related diseases. To address this demographic change, the Aging Biomarker Consortium (ABC) has launched the X-Age Project to develop a comprehensive aging evaluation system tailored to the Chinese population. Our goal is to identify robust biomarkers and construct composite aging clocks that capture biological age, defined as an individual's physiological and molecular state, across diverse Chinese cohorts.
View Article and Find Full Text PDFNat Aging
September 2025
Department of Clinical Molecular Biology, University of Oslo and Akershus University Hospital, Lørenskog, Norway.
Beyond their classical functions as redox cofactors, recent fundamental and clinical research has expanded our understanding of the diverse roles of nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucleotide phosphate (NADP) in signaling pathways, epigenetic regulation and energy homeostasis. Moreover, NAD and NADP influence numerous diseases as well as the processes of aging, and are emerging as targets for clinical intervention. Here, we summarize safety, bioavailability and efficacy data from NAD-related clinical trials, focusing on aging and neurodegenerative diseases.
View Article and Find Full Text PDFBiotechnol Lett
September 2025
Department of Chemical Engineering, Hongik University, Sangsu-dong, Mapo-gu, Seoul, 04066, Republic of Korea.
The cell surface display system employs carrier proteins to present target proteins on the outer membrane of cells. This system enables functional proteins to be exposed on the exterior of living cells without cell lysis, allowing direct interaction with the surrounding environment. A major limitation of conventional approaches is the difficulty in displaying large-sized enzymes or antibodies, despite their critical roles in applications requiring functional domains that must remain intact, such as catalytic or antigen-binding sites.
View Article and Find Full Text PDFEye (Lond)
September 2025
Genetics Laboratory, Metropolitan South Clinical Laboratory, Bellvitge University Hospital, Institut d'Investigació Biomèdica de Bellvitge (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain.
Background: Inherited retinal dystrophies (IRDs) are a genetically heterogeneous group of conditions, with approximately 40% of cases remaining unresolved after initial genetic testing. This study aimed to assess the impact of a personalised genomic approach integrating whole-exome sequencing (WES) reanalysis, whole-genome sequencing (WGS), customised gene panels and functional assays to improve diagnostic yield in unresolved cases.
Subjects/methods: We retrospectively reviewed a cohort of 597 individuals with IRDs, including 525 probands and 72 affected relatives.