Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
, a Gram-negative bacteria observed in some popular beverages, is considered safe and has been studied for its potential therapeutic benefits. In this study, we explored its effects on the inflammatory process, tissue integrity, differential gene expression, and microbiota composition in an experimental dextran sulfate sodium (DSS)-induced colitis model in mice. As a result, alleviated the symptoms caused by DSS administration, as indicated by reduced weight loss, disease activity index, a significant reduction in the colon weight/length ratio, and histopathological improvement. Also, could restore the mucosal barrier as well as increase the expression of and genes. An analysis of 16S rRNA sequences showed that alters gut microbiota, increasing abundance and decreasing . Furthermore, seems to be involved in potentiating a regulatory phenotype by inducing immunomodulatory genes like , , , and and reducing the relative mRNA expression of proinflammatory cytokines , , and . Our data suggest that could alleviate disease progression and be considered a possible probiotic adjuvant for pathologies of the bowel.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10672878 | PMC |
| http://dx.doi.org/10.3390/microorganisms11112793 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Phosvitin Alleviates Dextran Sulfate Sodium-Induced Colitis in Mice via Gut Microbiota Modulation.
J Agric Food Chem
September 2025
College of Food Science and Engineering, Northwest A&F University, Yangling 712100, China.
Dietary proteins have been demonstrated to alleviate ulcerative colitis. Phosvitin (PSV), a highly phosphorylated protein, possesses biological functions such as anti-inflammatory and antioxidant activities. This study aimed to investigate the preventive effects of PSV on dextran sulfate sodium (DSS)-induced colitis in mice and its underlying mechanisms.
View Article and Find Full Text PDFBranched-Chain Amino Acids Exacerbate Colitis Progression by Lowering Colonic Fumarate Levels.
Inflamm Bowel Dis
September 2025
Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal.
Background: Ulcerative colitis (UC) is a gastrointestinal inflammatory condition with an unclear etiology. Recent findings suggest that metabolites play a pivotal role in promoting intestinal health. We have previously observed a significant enrichment in colonic branched-chain amino acids (BCAAs) in resistant mice to colitis suggesting the potential role of these metabolites in UC development.
View Article and Find Full Text PDFPraeruptorin A alleviates DSS-induced acute ulcerative colitis in mice via the STAT-1/-3 pathway.
Am J Physiol Regul Integr Comp Physiol
September 2025
Laboratory of Anesthesia and Critical Care Medicine, National-Local Joint Engineering Research Centre of Translational Medicine of Anesthesiology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Ulcerative colitis (UC) is a serious inflammatory bowel disease with a significantly increasing incidence globally. Current treatment options often exhibit unstable efficacy and notable side effects, making the exploration of alternative therapies particularly important. Peucedanum praeruptorum Dunn, a traditional Chinese medicine, contains various bioactive compounds, among which praeruptorin A (PA) has garnered attention for its anti-inflammatory potential.
View Article and Find Full Text PDFIntestinal epithelial C/EBPβ deficiency impairs colitis-associated tumorigenesis by disrupting CXCL1/CXCL2/CXCL5-CXCR2-mediated neutrophil infiltration.
Acta Biochim Biophys Sin (Shanghai)
September 2025
State Key Laboratory of Analytical Chemistry for Life Sciences, School of Life Sciences, Nanjing University, Nanjing 210023, China.
Dysregulated transcription factors critically link chronic inflammation to oncogenesis in colitis-associated colorectal cancer (CAC), but their mechanistic roles remain incompletely understood. By integrating microarray and transcriptome sequencing data from ulcerative colitis (UC), colitis-associated cancer (CAC), and colorectal cancer (CRC) patients, we identify C/EBPβ as a key transcriptional regulator whose elevated expression inversely correlates with survival. In azoxymethane (AOM)/dextran sulfate sodium (DSS)-induced CAC models, intestinal epithelial C/EBPβ is upregulated during tumor progression, which is correlated with exacerbated tumor burden and neutrophil infiltration.
View Article and Find Full Text PDFUltrasonic-assisted three-phase partitioning with deep eutectic solvents for extraction of Nostoc commune Vauch polysaccharides and their anti-ulcerative colitis activity.
Int J Biol Macromol
September 2025
The Affiliated Dongguan Songshan Lake Central Hospital, Guangdong Provincial Key Laboratory of Research and Development of Natural Drugs, School of Pharmacy, Guangdong Medical University, Dongguan, 523808, China.
This study explores the extraction of polysaccharides from Nostoc commune Vauch. using ultrasonic-assisted three-phase partitioning with deep eutectic solvents (UA-TPP-DES). Response surface methodology was used to determine the optimized UA-TPP-DES conditions as follows: a 1: 2 M ratio of lauric acid to terpineol, 30 min of ultrasonication at 60 °C with 100 W power, 20 % moisture content, 20 % w/w (NH)SO concentration, and a 2: 1 top-to-bottom phase volume ratio.
View Article and Find Full Text PDF