Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.arbres.2023.11.002 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
New Cyclic Lipopeptide Compounds for Efficiently Inhibiting Cellular Inflammation and Collagen-Induced Arthritis in Mice.
J Med Chem
September 2025
Department of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, No.17, Third Section of Renmin South Road, Chengdu 610041, China.
Rheumatoid arthritis (RA) is a systemic autoimmune disease, and a large number of patients do not respond well to existing treatment strategies. Our previous report has discovered that the cyclic lipopeptide (CLP) daptomycin (DAP) has a good suppressive arthritis activity in mice. In this study, we have designed and synthesized five novel DAP-derived CLPs by structural optimization on the loop of DAP and further studied their anti-RA effects in vitro and in vivo.
View Article and Find Full Text PDFRobotic arm-assisted total knee arthroplasty reduces postoperative inflammatory response and blood loss compared to manual total knee arthroplasty: A matched-pairs analysis of 688 patients.
Knee Surg Sports Traumatol Arthrosc
September 2025
Department of Orthopaedic Surgery, School of Medicine, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.
Purpose: Robotic arm-assisted total knee arthroplasty (raTKA) has demonstrated several advantages over manual TKA (mTKA), including enhanced early recovery. Reduced soft tissue trauma and avoidance of femoral intramedullary canal opening have been hypothesised to lower the systemic inflammatory response. However, findings from previous small-cohort studies have been inconsistent.
View Article and Find Full Text PDFCausality between thyroid disease and psoriasis: Bidirectional Mendelian randomization analysis.
Medicine (Baltimore)
September 2025
Department of Health Statistics, School of Public Health, Shandong Second Medical University, Weifang, Shandong, China.
Both psoriasis and autoimmune thyroid diseases are characterized by chronic inflammation. The previous studies indicated a potential association between psoriasis and autoimmune thyroid diseases. However, the direction and nature of these relationships remain unclear.
View Article and Find Full Text PDFBidirectional Mendelian randomization study reveals causal relationships between polymyalgia rheumatica and serum metabolites.
Medicine (Baltimore)
September 2025
Department of Rheumatology and Immunology, Inner Mongolia Autonomous Region People's Hospital, Hohhot, China.
Polymyalgia rheumatica (PMR) is a prevalent chronic inflammatory disorder among the elderly, presenting diagnostic and therapeutic challenges. Existing treatments like glucocorticoids have significant side effects, and the molecular mechanisms of PMR remain unclear. This study employed a 2-sample bidirectional Mendelian randomization approach to explore the causal relationship between 1091 metabolites, 309 metabolite ratios, and PMR risk.
View Article and Find Full Text PDFEnhancing healthspan with Ashwagandha (Withania somnifera): a comprehensive review of its multifaceted geroprotective benefits.
Biogerontology
September 2025
School of Pharmacy and Biomolecular Sciences, Liverpool John Moores University, Liverpool, UK.
Ashwagandha (Withania somnifera), a revered herb in Ayurvedic medicine, has gained significant scientific recognition for its potential to promote healthy aging. Traditionally used as a Rasayana or rejuvenator, this potent adaptogen helps the body manage stress and enhance vitality. This review synthesises extensive evidence for its multifaceted anti-aging capabilities, which target key hallmarks of the aging process.
View Article and Find Full Text PDF