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http://dx.doi.org/10.1111/ijd.16904 | DOI Listing |
Pediatr Allergy Immunol
September 2025
Allergy Department, Hospital Clinic, University of Barcelona, Barcelona, Spain.
Cofactors are external factors that can lower the threshold dose of an allergen and amplify the severity of allergic reactions, turning mild or moderate responses into severe anaphylaxis. These include exercise, nonsteroidal anti-inflammatory drugs (NSAIDs), alcohol, menstruation, and infections. Initially described in relation to food allergens and physical activity or NSAIDs, these reactions have been labeled under various terms, such as food-dependent exercise-induced anaphylaxis (FDEIA), wheat-dependent exercise-induced anaphylaxis (WDEIA), and food-dependent NSAID-induced anaphylaxis (FDNIA).
View Article and Find Full Text PDFJ Cosmet Dermatol
August 2025
Department of Dermatology, Razi Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Background: Alopecia areata (AA) is an autoimmune condition resulting in hair loss, sometimes just in small patches but occasionally across larger areas like the entire scalp. For localized AA, treatments often involve injecting corticosteroids, such as triamcinolone acetonide (TrA), directly into the affected areas. Methotrexate (MTX), a drug known for its ability to suppress immune responses, has also been considered as an alternative.
View Article and Find Full Text PDFCureus
June 2025
Department of Dermatology, Venereology and Leprosy, Great Eastern Medical School and Hospital, Srikakulam, IND.
Background Pemphigus and pemphigoid disorders, as well as dermatitis herpetiformis, are all part of the diverse group of conditions known as autoimmune vesiculobullous/blistering disorders (AIBDs). These disorders are caused by autoantibodies that target intercellular or cell-matrix adhesion proteins and are clinically characterized by blisters or erosions of the skin and/or mucous membranes. The incidence peaks at 30-60 years with an equal incidence in men and women.
View Article and Find Full Text PDFChem Biodivers
July 2025
Pharmacognosy Department, Faculty of Pharmacy, Cairo University, Cairo, Egypt.
This review provides up-to-date and comprehensive information on Caralluma species native to Yemen, linking traditional uses, taxonomy, phytochemistry, biological activities, and toxicology to guide future research. From over 300 scientific database sources, it identifies approximately 25 Caralluma species across Yemen's diverse landscapes, many endemics, with species like Caralluma dolichocarpa, Caralluma chrysostephana, and Caralluma eremastrum classified as endangered. In Yemen and other Asian regions, Caralluma is traditionally used to manage diabetes, gastrointestinal disorders, inflammation, leprosy, obesity, and arthritis.
View Article and Find Full Text PDFHealth Sci Rep
May 2025
Department of Dermatology, Razi Hospital Tehran University of Medical Sciences Tehran Iran.
Background And Aims: Keloids are challenging lesions to manage due to their resistance to treatment and high recurrence rates. This study evaluated the efficacy of an intralesional injection combining triamcinolone acetonide, 5-fluorouracil, and hyaluronidase compared with triamcinolone monotherapy in treating keloids.
Methods: This single-blinded clinical trial involved 16 participants, block-randomized into two groups.