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Energy-based computing is a promising approach for addressing the rising demand for solving NP-hard problems across diverse domains, including logistics, artificial intelligence, cryptography, and optimization. Probabilistic computing utilizing pbits, which can be manufactured using the semiconductor process and seamlessly integrated with conventional processing units, stands out as an efficient candidate to meet these demands. Here, we propose a novel pbit unit using an NbO volatile memristor-based oscillator capable of generating probabilistic bits in a self-clocking manner. The noise-induced metal-insulator transition causes the probabilistic behavior, which can be effectively modeled using a multi-noise-induced stochastic process around the metal-insulator transition temperature. We demonstrate a memristive Boltzmann machine based on our proposed pbit and validate its feasibility by solving NP-hard problems. Furthermore, we propose a streamlined operation methodology that considers the autocorrelation of individual bits, enabling energy-efficient and high-performance probabilistic computing.
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http://dx.doi.org/10.1038/s41467-023-43085-6 | DOI Listing |
Biomed Eng Lett
September 2025
Department of Radiology, Guizhou International Science and Technology Cooperation Base of Precision Imaging for Diagnosis and Treatment, Guizhou Provincial People's Hospital, Guiyang, Guizhou China.
The generated lung nodule data plays an indispensable role in the development of intelligent assisted diagnosis of lung cancer. Existing generative models, primarily based on Generative Adversarial Networks (GANs) and Denoising Diffusion Probabilistic Models (DDPM), have demonstrated effectiveness but also come with certain limitations: GANs often produce artifacts and unnatural boundaries, and due to dataset limitations, they struggle with irregular nodules. While DDPMs are capable of generating a diverse range of nodules, their inherent randomness and lack of control limit their applicability in tasks such as segmentation.
View Article and Find Full Text PDFCell Rep Methods
August 2025
Interdepartmental Program in Computational Biology & Bioinformatics, Yale University, New Haven, CT 06511, USA; Department of Biostatistics, Yale University, New Haven, CT 06511, USA. Electronic address:
Single-cell multi-modal data integration has been an area of active research in recent years. However, it is difficult to unify the integration process of different omics in a pipeline and evaluate the contributions of data integration. In this article, we revisit the definition and contributions of multi-modal data integration and propose a strong and scalable method based on probabilistic deep learning with an explainable framework powered by statistical modeling to extract meaningful information after data integration.
View Article and Find Full Text PDFUnlabelled: Adaptive behavior requires integrating information from multiple sources. These sources can originate from distinct channels, such as internally maintained latent cognitive representations or externally presented sensory cues. Because these signals are often stochastic and carry inherent uncertainty, integration is challenging.
View Article and Find Full Text PDFJ Theor Biol
September 2025
School of Mathematics and Statistics, The University of Melbourne, Melbourne, Victoria, 3010, Australia; Melbourne Integrative Genomics, The University of Melbourne, Melbourne, Victoria, 3010, Australia. Electronic address:
Phylogenetic trees describe the relationships between species in the evolutionary process, and provide information about the rates of diversification. To understand the mechanisms behind macroevolution, we consider a class of multitype branching processes called Markovian binary trees (MBTs). MBTs allow for trait-based variation in diversification rates, and provide a flexible and realistic probabilistic model for phylogenetic trees.
View Article and Find Full Text PDFComput Biol Med
September 2025
Department of Mathematics, NIT Jamshedpur, Jharkhand 831014, India. Electronic address:
The behavior of blood viscosity is influenced by several physical factors, particularly hematocrit levels and vessel diameter. For a fixed hematocrit, apparent blood viscosity decreases with tube diameters in the range of 9μm to 1000μm, a phenomenon known as the Fåhræus-Lindqvist (FL) effect. Almost all existing models of the apparent blood viscosity are empirically proposed describing that viscosity exponentially increases with hematocrit.
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