Frontoparietal Hubs Leverage Probabilistic Representations and Integrated Uncertainty to Guide Cognitive Flexibility.

Unlabelled: Adaptive behavior requires integrating information from multiple sources. These sources can originate from distinct channels, such as internally maintained latent cognitive representations or externally presented sensory cues. Because these signals are often stochastic and carry inherent uncertainty, integration is challenging. However, the neural and computational mechanisms that support the integration of such stochastic information remain unknown. We introduce a computational neuroimaging framework to elucidate how brain systems integrate internally maintained and externally cued stochastic information to guide behavior. Neuroimaging data were collected from healthy adult human participants (both male and female). Our computational model estimates trial-by-trial beliefs about internally maintained latent states and externally presented perceptual cues, then integrates them into a unified joint probability distribution. The entropy of this joint distribution quantifies overall uncertainty, which enables continuous tracking of probabilistic task beliefs, prediction errors, and updating dynamics. Results showed that latent state beliefs are encoded in distinct regions from perceptual beliefs. Latent-state beliefs were encoded in the anterior middle frontal gyrus, mediodorsal thalamus, and inferior parietal lobule, whereas perceptual beliefs were encoded in spatially distinct regions including lateral temporo-occipital areas, intraparietal sulcus, and precentral sulcus. The integrated joint probability and its entropy converged in frontoparietal hub areas, notably middle frontal gyrus and intraparietal sulcus. Entropy adaptively reconfigured connectivity-first strengthening coupling with sensory regions, then motor and premotor regions that encode task output, and finally prediction error circuits. These findings suggest that frontoparietal hubs read out and resolve distributed uncertainty to flexibly guide behavior, revealing how frontoparietal systems implement cognitive integration.

Significance: Flexible human behavior often depends on integrating information from multiple sources, such as memory and perception, each of which can be corrupted by noise. For example, a driver must integrate traffic signals (external cues) with their destination plan (internal goals) to decide when to turn. This study reveals how the human brain integrates multiple information sources to guide flexible behavior. More specifically, distinct brain regions encode internal beliefs and external sensory representations, while frontoparietal regions integrate this information and dynamically adjust connectivity in response to input noise. These findings provide a complete account of how the brain encodes and integrates multiple inputs to guide adaptive behavior.