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http://dx.doi.org/10.7326/L23-0410 | DOI Listing |
Diabetologia
July 2025
Internal Medicine Department, Endocrine Division (SEMPR), Universidade Federal do Parana, Curitiba, Brazil.
J Dairy Res
November 2024
Research, Teaching and Extension Center in Livestock (NUPEEC), Federal University of Pelotas (UFPel), 96160-000, Pelotas, Brazil.
This study aimed to evaluate the effect of marine-based rumen buffer () supplementation on rumen health as well as milk yield and composition and also behavioural and metabolic parameters of dairy cows. Thirty-six lactating multiparous Holstein cows were used with a milk yield average of 39 kg/d and 64 d in milk. The experiment was conducted over 60 d using two groups: control (CON; = 18) was supplemented with sodium bicarbonate at 1.
View Article and Find Full Text PDFESMO Open
March 2025
Early Drug Development Unit, Vall d'Hebron Institute of Oncology (VHIO), Vall d'Hebron University Hospital, Barcelona, Spain.
Background: KO-947, a potent, intravenously administered, extracellular signal-regulated kinase (ERK) inhibitor, has demonstrated activity in preclinical models. This phase I trial of KO-947 evaluated maximum tolerated dose (MTD), safety, and pharmacokinetics in patients with relapsed/refractory solid tumors.
Materials And Methods: This multicenter, open-label, dose-escalation study evaluated KO-947 0.
Clin Cancer Res
February 2025
Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts.
Purpose: FHD-609, a potent, selective, heterobifunctional degrader of bromodomain-containing protein 9 (BRD9), was evaluated for treating patients with advanced synovial sarcoma or SMARCB1-deficient tumors.
Patients And Methods: In this multinational, open-label, phase I study (NCT04965753), patients received FHD-609 intravenously at escalating doses either twice weekly (5-80 mg; n = 40) or once weekly (40-120 mg; n = 15).
Results: Fifty-five patients received FHD-609 for a median of 43 days.