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One of the goals of pathology is to standardize laboratory practices to increase the precision and effectiveness of diagnostic testing, which will ultimately enhance patient care and results. Standardization is crucial in the domains of tissue processing, analysis, and reporting. To enhance diagnostic testing, innovative technologies are also being created and put into use. Furthermore, although problems like algorithm training and data privacy issues still need to be resolved, digital pathology and artificial intelligence are emerging in a structured manner. Overall, for the field of pathology to advance and for patient care to be improved, standard laboratory practices and innovative technologies must be adopted. In this paper, we describe the state-of-the-art of automation in pathology laboratories in order to lead technological progress and evolution. By anticipating laboratory needs and demands, the aim is to inspire innovation tools and processes as positively transformative support for operators, organizations, and patients.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11062949 | PMC |
http://dx.doi.org/10.1007/s00428-023-03637-z | DOI Listing |
The morphological patterns of lung adenocarcinoma (LUAD) are recognized for their prognostic significance, with ongoing debate regarding the optimal grading strategy. This study aimed to develop a clinical-grade, fully quantitative, and automated tool for pattern classification/quantification (PATQUANT), to evaluate existing grading strategies, and determine the optimal grading system. PATQUANT was trained on a high-quality dataset, manually annotated by expert pathologists.
View Article and Find Full Text PDFAppl Biosaf
August 2025
Global Center for Health Security, University of Nebraska Medical Center, Omaha, Nebraska, USA.
Introduction: Laboratory-acquired infections (LAIs) from exposure to infectious biological pathogens during laboratory operations present ongoing challenges despite modern biosafety measures. Notably, LAIs attributed to inhaling infectious aerosols continue to occur.
Objective: This review aims to enhance understanding of the risks of LAIs associated with infectious aerosols.
Exp Clin Transplant
August 2025
>From the University of Maryland School of Medicine, Baltimore, Maryland, USA.
The development of non-Hodgkin lymphoma following liver transplant is rare. We present an unusual case of a 40-year-old female patient with morbid obesity who had undergone a deceased donor liver transplant for an unresectable neuroendocrine tumor of the liver 12 years ago. She presented with a lesion in the tail of pancreas that was suggestive of a recurrent neuroendocrine tumor.
View Article and Find Full Text PDFGenome Biol
September 2025
Department of Clinical Pharmacy, Alfred E. Mann School of Pharmacy and Pharmaceutical Sciences, University of Southern California, Los Angeles, CA, 90089, USA.
Background: Recent advances in high-throughput sequencing technologies have enabled the collection and sharing of a massive amount of omics data, along with its associated metadata-descriptive information that contextualizes the data, including phenotypic traits and experimental design. Enhancing metadata availability is critical to ensure data reusability and reproducibility and to facilitate novel biomedical discoveries through effective data reuse. Yet, incomplete metadata accompanying public omics data may hinder reproducibility and reusability and limit secondary analyses.
View Article and Find Full Text PDFJ Robot Surg
September 2025
Department of Gynecologic Oncology, Moffitt Cancer Center, 12902 USF Magnolia Drive, Tampa, FL, 33612, USA.
This study was conducted to investigate the techniques and complications of enlarged uterine extraction during minimally invasive surgery for uterine malignancy. The electronic medical record was queried for patients with uterine malignancy and enlarged uterus (≥ 250 g) who underwent primary hysterectomy with laparoscopic or robotic approach. Statistical analysis was performed using Fisher's exact test for categorical variables and Kruskal-Wallis test for continuous variables.
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