Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Background: Few studies have examined the relationship between non-cognitive factors and activities of daily living (ADL) according to Alzheimer's disease (AD) stage.
Objective: We aimed to identify the differences in non-cognitive factors according to AD stages and their involvement in basic and instrumental ADL performance by using intrinsic capacity (IC) in groups with cognition ranging from normal to moderate or severe AD.
Methods: We enrolled 6397 patients aged≥65 years who visited our memory clinic. Non-cognitive IC was assessed using the locomotion, sensory, vitality, and psychological domains. Multiple logistic regression was performed to identify how non-cognitive IC declines over the AD course and examine the correlation between non-cognitive IC and basic and instrumental ADL performance.
Results: Non-cognitive IC declined from the initial AD stage and was significantly correlated with both basic and instrumental ADL performance from the aMCI stage through all AD stages. In particular, the relationship between IC and basic ADL was stronger in mild and moderate to severe AD than in the aMCI stage. On the other hand, the relationship between IC and instrumental ADL was stronger in aMCI than in later AD stages.
Conclusions: The results show non-cognitive factors, which decline from the aMCI stage, are correlated with ADL performance from the aMCI stage to almost all AD stages. Considering that the relationship strength varied by ADL type and AD stage, an approach tailored to ADL type and AD stage targeting multiple risk factors is likely needed for effectively preventing ADL performance declines.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.3233/JAD-230786 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Chronic pain and decline in activities of daily living among community-dwelling older adults: a systematic review of longitudinal studies.
Eur Geriatr Med
September 2025
Department of Social Science, Center for Gerontology and Social Science, Research Institute, National Center for Geriatrics and Gerontology, Obu, Aichi, Japan.
Purpose: To investigate the longitudinal association between chronic pain and decline in activity of daily living (ADL) among community-dwelling older adults aged ≥ 60 years.
Methods: In this systematic review of prospective longitudinal studies with narrative synthesis, a comprehensive literature search was conducted using PubMed and Embase using free-text words and MeSH terms on February 3, 2025. Longitudinal studies that quantitatively assessed ADL at two or more time points and pain at least once were included.
Frailty and Cognitive Decline in Hospitalized Elderly Patients: Associations with Clinical and Laboratory Parameters.
Med Sci Monit
September 2025
Department of Geriatric Nursing, Medical University of Warsaw, Warsaw, Poland.
BACKGROUND Frailty syndrome (FS) and cognitive impairment are major geriatric concerns, particularly prevalent among hospitalized older adults. The primary objective of this study was to assess the co-occurrence of FS and cognitive impairment in hospitalized geriatric patients. Additionally, the study analyzed the relationship of these conditions with functional status, fall risk, sensory deficits, depressive symptoms, and selected prognostic laboratory parameters.
View Article and Find Full Text PDFContrast Sensitivity Impairment Is Associated With Limitations of Physical Functioning and Activities of Daily Living Among Older Adults.
J Aging Health
September 2025
Department of Ophthalmology and Visual Sciences, Michigan Medicine, University of Michigan, Ann Arbor, MI, USA.
Contrast sensitivity (CS), the ability to see objects against their background, is an important component of visual function. The effect of contrast sensitivity impairment (CSI) on physical functioning (PF) is not well documented. This study obtained data from the Aging, Demographics, and Memory Study.
View Article and Find Full Text PDFHow does intergenerational support from adult children shape the intrinsic capacity of older adults? Empirical evidence from the CHARLS.
Aging Clin Exp Res
August 2025
Department of Neurosurgery, Deyang People's Hospital, Deyang, Sichuan, China.
Background: As China undergoes a rapid demographic shift toward population aging, a critical challenge has emerged for healthy aging policy: how can intergenerational support from adult children be leveraged to maintain and improve the functional ability of older adults? Drawing on nationally representative data, this study investigates the association between such support and the intrinsic capacity of older adults, and explores the pathways through which it operates.
Methods: This study utilizes data from the 2015, 2018, and 2020 waves of the China health and retirement longitudinal study (CHARLS). A multidimensional index of intergenerational support from adult children is constructed, incorporating financial support, emotional closeness, and caregiving.
Association between activities of daily living and depression symptoms among older adults in China: A nationally representative cross-sectional survey.
BMC Psychol
August 2025
Brown School of Social Work, Washington University in St. Louis, MO, St. Louis, 63130, USA.
Objective: Impaired Activities of Daily Living (ADL) can have a negative impact on the psychological well-being of older adults. This study categorises ADL into Basic Activities of Daily Living (BADL) and Instrumental Activities of Daily Living (IADL). By utilising nationally representative cross-sectional data, we explore the association between ADL and BADL limitations and depressive symptoms among the elderly population in China.
View Article and Find Full Text PDF