98%
921
2 minutes
20
Background: Following total laryngectomy (TL) or laryngopharyngectomy (TLP), patients may develop strictures that require multiple dilations to treat. However, the risk factors associated with dysphagia refractory to a single dilation are unknown.
Methods: Single-institution retrospective review of patients who underwent at least one stricture dilation after TL/TLP between March 2013 and March 2022.
Results: A total of 49 patients underwent stricture dilation after TL/TLP. Thirty-five (71%) underwent multiple dilations. Pharyngocutaneous fistula, primary chemoradiation therapy, and a shorter time interval from TL/TLP to first dilation were independently associated with dysphagia requiring multiple dilations. Patients in the multiple dilations group had a higher rate of limited diet and G-tube dependence compared to patients in the single dilation group.
Conclusions: Shorter time interval to stricture formation is a prognostic indicator of the need for multiple dilations following TL/TLP. Patients requiring multiple dilations are at increased risk of persistent dysphagia long-term.
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.1002/hed.27545 | DOI Listing |
PLoS One
September 2025
Department of Urology, Kanazawa Medical University, Kahoku, Ishikawa, Japan.
Calcium oxalate (CaOx) stones are prevalent in urinary tract stone disease. While their formation can be induced in rats by administering ethylene glycol and vitamin D, the initial nucleation and formation processes are unclear. Here, we aimed to determine where CaOx crystals initially form, examine the associated histological and morphological changes, and clarify the genes whose expression varies at those sites and their function.
View Article and Find Full Text PDFKhirurgiia (Mosk)
September 2025
Mandryka Central Military Clinical Hospital, Moscow, Russia.
Widespread fragmentation shells in combat operations with frequent multiple damage to organs and systems force to use all available diagnostic methods for treating severe injuries including lesion of great vessels of extremities. One of the consequences of these lesions is arteriovenous fistula (AVF). The last one may be asymptomatic at first.
View Article and Find Full Text PDFZhonghua Bing Li Xue Za Zhi
September 2025
Department of Pathology, Henan Provincial People's Hospital, Zhengzhou University People's Hospital, Zhengzhou 450003, China.
To investigate the clinicopathological features, genetic characteristics, and differential diagnosis of glomangiomatosis with uncertain malignant potential. Two cases of glomangiomatosis with uncertain malignant potential were collected at Henan Provincial People's Hospital from 2013 and 2023. Immunohistochemistry and next generation sequencing (DNA-seq) were used to detect the related protein and gene variation.
View Article and Find Full Text PDFBackground: Activating Transcription Factor 4 (ATF4) functions as a transcriptional regulator in various cell types and tissues under both physiological and pathological conditions. While previous studies have linked ATF4 activation with promoting cardiomyocyte (CM) death in dilated cardiomyopathy (DCM), atrial fibrillation, and heart failure, its role in developing CMs remains unexplored.
Methods: We generated multiple distinct CM-specific ( , and ) and global knockout ( and ) mouse models targeting different regions, as well as cardiomyocyte-specific deletion of to study cardiac phenotypes.
Eur Heart J Case Rep
September 2025
Arrhythmia Unit, Department of Cardiology, Hospital Juan Ramon Jimenez, Ronda Norte S/N, Huelva 21005, Spain.
Background: Becker muscular dystrophy (BMD) is frequently associated with cardiac involvement. The underlying pathoanatomical substrate includes replacement of cardiomyocytes by fibrous tissue, leading to extensive myocardial fibrosis of the posterolateral wall of the left ventricular (LV) epicardium. Cardiac arrhythmias, including ventricular tachycardia (VT), are common in this condition, particularly when LV ejection fraction (LVEF) declines.
View Article and Find Full Text PDF