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| http://dx.doi.org/10.1080/08880018.2023.2273880 | DOI Listing |
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Background: Functional immune reconstitution (IR) is a key factor in determining the success of hematopoietic stem cell transplantation (HSCT). IR depends on a number of factors and is typically delayed by ex vivo T cell depletion of the graft. αβ T cell depletion (αβ TCD) platform was reported to be associated with improved IR.
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Pediatr Blood Cancer
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Division of Hematology/Oncology, Children's Hospital of Zhejiang University School of Medicine, Hangzhou, China.
Immunotherapy with ex vivo-expanded donor-derived NK cells after haploidentical HSCT in pediatric patients with AML: a phase I pilot study.
Curr Res Transl Med
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Hematologic Malignancies Research Center, Research Institute for Oncology, Hematology and Cell Therapy, Tehran University of Medical Sciences, Tehran, Iran.
Background: Post-transplant relapse remains a considerable challenge for achieving successful outcomes in pediatric patients with acute myeloid leukemia (AML) receiving haploidentical hematopoietic stem cell transplantation (HSCT). Adoptive immune cell therapy strategies utilizing highly purified donor-derived natural killer (NK) cells have been extensively explored in various transplantation settings, demonstrating promise in preventing disease recurrence, especially in pediatric AML patients.
Methods: Five pediatric and adolescent patients with high-risk AML were included in this pilot study and received haploidentical HSCT.
Autologous Cord Blood Transplantation for Idiopathic Severe Aplastic Anemia.
J Pediatr Hematol Oncol
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Cord blood units are seldom used for autologous transplantation and selection criteria have not been defined. A 6-year-old male with severe aplastic anemia received an autologous cord blood transplantation containing total nucleated cells (TNC) 2.0×107/kg and CD34+0.
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