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Cognitive dysfunction (CD) is a neurologic complication of pediatric systemic lupus erythematosus (SLE) that remains poorly understood and understudied, despite the potential negative effects of CD on long-term socioeconomic status and quality of life. Data regarding the prevalence and risk factors for CD in pediatric SLE as well as the optimal screening, treatment, and long-term outcomes for CD are lacking. In this review, we present current knowledge on CD in pediatric SLE with a focus on the application to clinical practice. We discuss the challenges in diagnosis, clinical screening methods, potential impacts, and interventions for this complication. Finally, we discuss the remaining gaps in our knowledge of CD in pediatric SLE, and avenues for future research efforts.
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http://dx.doi.org/10.1080/09297049.2023.2273573 | DOI Listing |
Front Pediatr
August 2025
Department of Rheumatology and Immunology, Tianjin Children's Hospital (Children's Hospital, Tianjin University), Tianjin Key Laboratory of Birth Defects for Prevention and Treatment, Tianjin, China.
Type 1 diabetes mellitus (T1DM) and systemic lupus erythematosus (SLE) are both autoimmune diseases influenced by multiple genetic and environmental factors, but rarely coexist. This case describes a 13-year-old girl with early onset of T1DM who was diagnosed with SLE 12 years later, highlighting diagnostic and therapeutic challenges, particularly in distinguishing kidney involvement and management without exacerbating hyperglycemia. The patient presented with edema of the eyelids and lower limbs.
View Article and Find Full Text PDFRMD Open
September 2025
Department of Rheumatology and Department of Internal Medicine, Ghent University Hospital, Unit for Molecular Immunology and Inflammation, Flemish Institute for Biotechnology, Inflammation Research Center, University of Ghent, Ghent, Belgium.
Objectives: To evaluate whether patients with systemic lupus erythematosus (SLE) have different nailfold videocapillaroscopy (NVC) findings compared with healthy controls (HCs) and whether there is an association between NVC abnormalities and disease activity, clinical and/or laboratory features in SLE.
Methods: This is an observational, multicentre, international, matched case-control study. 381 subjects (203 patients with SLE and 178 HCs) were enrolled from 16 centres in 10 countries.
Int J Rheum Dis
September 2025
Department of Pediatrics, Facultad de Medicina, Universidad Nacional de Asunción, Asunción, Paraguay.
Introduction: Vitamin D plays a crucial role in modulating the immune system. Numerous studies have elucidated the association between low serum levels of vitamin D and autoimmune diseases. Vitamin D deficiency has been implicated in systemic lupus erythematosus, rheumatoid arthritis (RA), Hashimoto's thyroiditis, juvenile dermatomyositis, inflammatory bowel disease, among others.
View Article and Find Full Text PDFInt J Surg Case Rep
August 2025
Paediatrics Medicine, Services Hospital, Lahore, Pakistan.
Introduction: Adult intussusception is rare, and its occurrence following colonoscopy-especially after multiple polypectomies-is exceptionally uncommon. This case highlights a rare post-endoscopic complication with implications for early diagnosis and management.
Case Presentation: A 55-year-old man presented with abdominal pain, bloating, and nausea 24 h after colonoscopy with removal of nine polyps via cold snare technique.
Cureus
July 2025
Research and Education Division, Medical Care and Research, Mérida, MEX.
Autoimmune diseases present a clinical challenge for young women of childbearing age since pregnancy can affect their progression and lead to complications for both mother and baby. Systemic lupus erythematosus (SLE) is of particular interest in this context due to its association with an increased risk of spontaneous abortion, foetal death, pre-eclampsia, intrauterine growth restriction, preterm delivery, and various neonatal manifestations, including thrombocytopenia. In this context, autoimmune neonatal thrombocytopenia, caused by the transplacental transfer of maternal autoantibodies, may be the first sign of an undiagnosed autoimmune disease in the mother.
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