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http://dx.doi.org/10.1093/ehjci/jead267 | DOI Listing |
Nucleic Acids Res
September 2025
Ohio State Biochemistry Graduate Program, The Ohio State University, Columbus, OH 43210, United States.
Nucleosome repositioning is essential for establishing nucleosome-depleted regions to initiate transcription. This process has been extensively studied using structural, biochemical, and single-molecule approaches, which require homogeneously positioned nucleosomes. This is often achieved using the Widom 601 sequence, a highly efficient nucleosome-positioning element (NPE) selected for its unusually strong binding to the H3-H4 histone tetramer.
View Article and Find Full Text PDFSignal Transduct Target Ther
September 2025
Beijing Key Laboratory of Surveillance, Early Warning and Pathogen Research on Emerging Infectious Diseases, Beijing Research Center for Respiratory Infectious Diseases, Public Health Emergency Management Innovation Center, Beijing Center for Disease Prevention and Control, Beijing, China. wangqy@bj
In November 2024, there was an unusual surge in human metapneumovirus (hMPV) infection cases in Beijing. We performed an epidemiological investigation among cases with acute respiratory tract infection (ARTI). We enrolled ARTI cases from 35 sentinel hospitals, collected samples and medical records, conducted comprehensive pathogen testing, sequenced target genes or whole genomes, and performed phylogenetic analysis.
View Article and Find Full Text PDFEur J Med Chem
August 2025
Department of Pharmacy, University of Pisa, Via Bonanno 6/33, Pisa, Italy. Electronic address:
A set of small molecules containing an unusual sp-rich heterobicyclic scaffold were prepared and evaluated in vitro for their ability to increase GLP-1 secretion in STC-1 cells and to protect SH-SY5Y cells from acute and chronic damage induced by glucose and methylglyoxal, respectively. The results obtained showed that some compounds, especially those containing an electron-withdrawing and/or lipophilic group at the meta position of the aryl moiety present at position 9, are effective non-covalent TRPA1 agonists. The lead compound so far individuated (compound 4b) was also prepared by asymmetric synthesis in both enantiomeric forms.
View Article and Find Full Text PDFPlant Cell
September 2025
Department of Life Sciences, Imperial College London, London SW7 2AZ, UK.
Communication between cellular organelles is essential for mounting effective innate immune responses. The transport of organelles to pathogen penetration sites and their assembly around the host membrane, which delineates the plant-pathogen interface, are well-documented. However, whether organelles associate with these specialized interfaces, and the extent to which this process contributes to immunity, remain unknown.
View Article and Find Full Text PDFJ Am Chem Soc
September 2025
Weill Institute for Cell and Molecular Biology, Cornell University, Ithaca, New York 14853, United States.
Most eukaryotic membranes comprise phospholipids bearing two hydrophobic tails, but -acylphosphatidylethanolamine (NAPE) stands out as a long-known but poorly understood phospholipid with three hydrophobic groups. What little attention NAPE has received has been devoted to understanding its metabolic functions as a precursor to -acylethanolamine (NAE), a bioactive lipid that acts as an endocannabinoid. Yet, levels of NAPE increase during myocardial infarction and ischemia, suggesting potential signaling roles for this lipid.
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