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In the past three decades, the use of opioids has risen tremendously. Pain was named the "fifth patient vital sign" in the 1990s, and from that point, opioid usage has continued to grow throughout the 2010s leading to its recognition as a crisis. The United States is responsible for 80% of the global opioid usage while only accounting for less than 5% of the global population. Previously opioids were mostly used to treat acute pain, however, opioids have been most recently used to manage chronic pain as well. The opioid crisis has presented new challenges in treating pain while preventing the abuse of these medications in a system that lacks standardization of treatment guidelines across the United States. Therefore, the authors of this review examine the current national recommendations to help manage the ongoing opioid crisis and explore how they may impact orthopedic patient care.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10578957 | PMC |
http://dx.doi.org/10.7759/cureus.45374 | DOI Listing |
Br J Health Psychol
September 2025
Manchester Centre for Health Psychology, School of Health Sciences, University of Manchester, Manchester, UK.
Objective: This study applied the Theoretical Domains Framework (TDF) to explore the barriers and enablers to optimizing post-operative pain management and supporting safe opioid use from the perspectives of both patients and health care professionals, applying the Theoretical Domains Framework (TDF).
Design: Experience-based co-design (EBCD) qualitative study.
Methods: In the initial phase of the EBCD approach, focus groups were conducted comprising 20 participants, including 8 patients and 12 health care professionals involved in post-operative care.
Medicine (Baltimore)
September 2025
Department of Anesthesiology, The First Affiliated Hospital of Traditional Chinese Medicine of Chengdu Medical College, XinDu Hospital of Traditional Chinese Medicine, Chengdu, China.
Background: With ultrasound-guided nerve block technology being increasingly used in hip surgery, the choice between fascia iliaca block (FIB) and lumbar plexus block (LPB) is still inconclusive. This study aims to evaluate the advantages and disadvantages of FIB and LPB in hip surgery.
Methods: PubMed, Web of Science, Cochrane Library, Embase, and CNKI were searched from inception to October 4, 2022.
J Cancer Res Ther
September 2025
Department of Anesthesiology, Cardiovascular Institute, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China.
Background: This study evaluated the efficacy and safety of esketamine plus dexmedetomidine for sedation and analgesia during computed tomography (CT)-guided lung tumor percutaneous microwave ablation (MWA).
Methods: Patients undergoing CT-guided percutaneous MWA of lung tumors were randomly divided into two groups: esketamine plus dexmedetomidine (Group E) and sufentanil plus dexmedetomidine (Group S). The patients' general information, mean arterial pressure (MAP), heart rate (HR), peripheral oxygen saturation, respiratory rate (RR), partial pressure of end-tidal carbon dioxide, bispectral index, and Ramsay sedation score were recorded before anesthesia administration (T0), after dexmedetomidine loading dose (T1), during percutaneous puncture (T2), during ablation (T3), at the end of surgery (T4), and during recovery of consciousness (T5).
J Opioid Manag
September 2025
Rush University Medical Center, Chicago, Illinois. ORCID: https://orcid.org/0000-0003-2531-5976.
Objectives: To investigate post-operative opioid use, functionality, and overall survival following internal fixation for pathologic or impending fractures at 3 and 6 months.
Background: Pathologic and impending fractures commonly occur in the proximal femur, and patients may be prescribed opioids prior to surgery and often require opioids for post-operative pain relief. This study compared post-operative opiate usage and ambulatory functional status in patients with impending versus pathologic fractures in the proximal femur.
Pain management in intensive care units (ICUs) is crucial for improving patient outcomes. Remifentanil, an ultra-short-acting opioid, is metabolized independently of renal and hepatic function, making it an attractive analgesic. This article discusses the pharmacological effects of remifentanil, its usage, and potential side effects in the ICU, current evidence, and clinical situations where its use is preferred.
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