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Article Abstract
High-resolution crystal structures of lysozyme in the presence of the potential drug V O(acetylacetonato) under two different experimental conditions have been solved. The crystallographic study reveals the loss of the ligands, the oxidation of V to V and the subsequent formation of adducts of the protein with two different polyoxidovanadates: [V O ] , which interacts with lysozyme non-covalently, and the unprecedented [V O (NO )] , which is covalenty bound to the side chain of an aspartate residue of symmetry related molecules.
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