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http://dx.doi.org/10.1002/ccd.30823 | DOI Listing |
Int J Comput Assist Radiol Surg
September 2025
Institute of Computer Science, Friedrich-Schiller-Universität, Fürstengraben 1, 07743, Jena, Thuringia, Germany.
Purpose: Cerebral aneurysms are blood-filled bulges that form at weak points in blood vessel walls, and their rupture can lead to life-threatening consequences. Given the high risk associated with these aneurysms, thorough examination and analysis are essential for determining appropriate treatment. While existing tools such as ANEULYSIS and its web-based counterpart WEBANEULYSIS provide interactive means for analyzing simulated aneurysm data, they lack support for collaborative analysis, which is crucial for enhancing interpretation and improving treatment decisions in medical team meetings.
View Article and Find Full Text PDFBiol Cybern
September 2025
Department of Mechanical Science and Engineering, University of Illinois Urbana-Champaign, 61801, IL, USA.
In this article, a biophysically realistic model of a soft octopus arm with internal musculature is presented. The modeling is motivated by experimental observations of sensorimotor control where an arm localizes and reaches a target. Major contributions of this article are: (i) development of models to capture the mechanical properties of arm musculature, the electrical properties of the arm peripheral nervous system (PNS), and the coupling of PNS with muscular contractions; (ii) modeling the arm sensory system, including chemosensing and proprioception; and (iii) algorithms for sensorimotor control, which include a novel feedback neural motor control law for mimicking target-oriented arm reaching motions, and a novel consensus algorithm for solving sensing problems such as locating a food source from local chemical sensory information (exogenous) and arm deformation information (endogenous).
View Article and Find Full Text PDFMetab Brain Dis
September 2025
Department of Pharmacology, SVKM's Dr Bhanuben Nanavati College of Pharmacy, V.M. Road, Vile Parle (W), Mumbai, India.
This study aimed to evaluate the antidepressant potential of Nitazoxanide (NTZ), an antiprotozoal drug with known anti-inflammatory and neuroprotective properties, in a chronic unpredictable mild stress (CUMS)-induced mice model of depression. NTZ was administered at doses of 75, 150, and 300 mg/kg, and its effects were assessed through a series of behavioral tests, including the forced swim test, tail suspension test, actophotometer test, and social interaction test. NTZ treatment at 150 and 300 mg/kg significantly improved behavioral and biochemical outcomes, relieving depressive-like symptoms and restoring neurochemical balance.
View Article and Find Full Text PDFDiabetologia
September 2025
Center for Clinical Metabolic Research, Gentofte Hospital, University of Copenhagen, Hellerup, Denmark.
Aims/hypothesis: Alpha cell dysregulation is an integral part of type 2 diabetes pathophysiology, increasing fasting as well as postprandial glucose concentrations. Alpha cell dysregulation occurs in tandem with the development of insulin resistance and changes in beta cell function. Our aim was to investigate, using mathematical modelling, the role of alpha cell dysregulation in beta cell compensatory insulin secretion and subsequent failure in the progression from normoglycaemia to type 2 diabetes defined by ADA criteria.
View Article and Find Full Text PDFJ Cancer Res Clin Oncol
September 2025
Cancer Treatment and Nuclear Cardiology Department, Al Azhar University, Cairo, Egypt.
Background: High-dose-rate (HDR) brachytherapy is essential in the treatment of locally advanced cervical cancer. While Iridium-192 (Ir-192) is commonly used, its short half-life imposes logistical and financial constraints, particularly in low- and middle-income countries (LMICs). Cobalt-60 (Co-60), with a longer half-life and lower operational costs, is a viable alternative.
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