Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Background: As an indicator to evaluate the risk of fracture in diffuse idiopathic skeletal hyperostosis, the maximum number of vertebral bodies' bone cross-linked with contiguous adjacent vertebrae (max VB) was developed. This study retrospectively investigates the relationship between max VB, bone mineral density (BMD), and bone metabolic markers (BMM).
Methods: In this cross-sectional study (from April 2010 to January 2022), males (n = 114) with various max VB from the thoracic vertebra to the sacrum, measured using computed tomography scans, were selected to assess femur BMD and BMM. The association of max VB with the total type I procollagen N-terminal propeptide (P1NP), tartrate-resistant acid phosphatase 5b (TRACP-5b), and bone turnover ratio (BTR = TRACP-5b/P1NP) as well as its relationship with femur BMD with P1NP and TRACP-5b, were investigated. Furthermore, the relationship between P1NP and TRACP-5b was investigated.
Results: P1NP increased in proportion to max VB and TRACP-5b increased in proportion to P1NP. Moreover, BTR was inversely proportional to max VB. Finally, femur BMD was inversely proportional to P1NP and TRACP-5b.
Conclusion: As max VB increased with P1NP-a potential osteogenesis indicator-and BTR was inversely proportional to max VB with compensatory TRACP-5b increase, max VB can be considered as a possible predictor of bone fusion.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10503207 | PMC |
| http://dx.doi.org/10.1186/s12891-023-06833-9 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Effect of comorbidities and multimorbidity on bone mineral density in patients with osteoporosis.
Arch Osteoporos
September 2025
Internal Medicine Service, Río Hortega University Hospital, Valladolid, Spain.
Unlabelled: This retrospective cohort study analysed a total of 344 patients from the OSTEOMED registry with matched baseline and follow-up DXA data, finding that comorbidities such as nephrolithiasis, hypertension or coronary heart disease may influence the response to prescribed anti-osteoporotic treatment.
Purpose: To determine: 1) comorbidities associated with reduced bone mineral density (BMD), T-score and Z-score at the lumbar spine (L1 to L4 vertebrae), femoral neck and total hip; and 2) the role of multimorbidity (≥ 2 comorbidities) in reduced BMD, T-score and Z-score at the lumbar spine, femoral neck and total hip.
Methods: Retrospective cohort study analyzing patients [319 females (92.
Association of Energy, Macronutrients, and Fiber Intakes with Bone Health in Adolescent Athletes.
Calcif Tissue Int
September 2025
Department of Physical Education, Center for Health and Sports Sciences, Santa Catarina State University, Rua Pascoal Simone, 358, Coqueiros, Florianópolis, State of Santa Catarina, CEP: 88080-350, Brazil.
This study investigated the association between energy and macronutrient intake and bone health in 63 adolescents of both sexes who participated in volleyball, track and field, or swimming. Bone mineral content (BMC) and density (BMD) of the total body less head (TBLH), lumbar spine (L1-L4), and femoral neck were assessed using DXA. Bone geometry parameters, including cross-sectional area (CSA), cross-sectional moment of inertia (CSMI), and section modulus, were estimated.
View Article and Find Full Text PDFRelationship with sex-based anatomical differences to lower extremity injury severity in frontal crashes.
Traffic Inj Prev
September 2025
Center for Applied Biomechanics, University of Virginia, Charlottesville, Virginia.
Objective: Multiple studies have demonstrated an increased risk of lower extremity injuries for females in frontal crashes. This study aimed to investigate whether sex-based anatomical differences, as measured on computed tomography (CT) scans of the abdomen and pelvis, contribute to lower extremity injury risk.
Methods: The Crash Injury Research and Engineering Network (CIREN) database (2017-2023) was queried for frontal collisions.
Bone health in a U.K. cohort of youth living with perinatally acquired HIV-1: a longitudinal study.
J Int AIDS Soc
September 2025
Department of Infectious Diseases, Imperial College London, London, UK.
Introduction: Low bone mineral density (BMD) has been described in children and young people with perinatally acquired HIV (PHIV), which may be related to both traditional (e.g. low body mass index and malnutrition) and HIV-related risk factors (e.
View Article and Find Full Text PDFSimilar femoral stem fixation but less metaphyseal loss of bone mineral density with a taper-wedge design and diaphyseal bone preservation with a long and round-tapered design: a 5-year randomized RSA and DXA study of 50 patients.
Acta Orthop
September 2025
Department of Orthopaedics, Aarhus University Hospital; Department of Clinical Medicine, Aarhus University, Denmark.
Background And Purpose: The new Tri-Lock bone -preserving stem with a collarless proximal-coated tapered-wedge design was compared with a classic well-proven collarless proximal-coated long and round-tapered design. Our primary aim was to compare femoral stem fixation (subsidence) of the Tri-Lock stem with the classic Summit stem, and secondarily to compare the change in periprosthetic bone mineral density (BMD) and PROMS between stem groups.
Methods: In a patient-blinded randomized controlled trial, 52 patients at mean age 60 (SD 6) received cementless Tri-Lock (n = 26) or Summit (n = 26) femoral stems with a cementless Pinnacle cup, a cross-linked polyethylene liner, and a CoCr head.