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Current guidelines of aortic stenosis (AS) management focus on valve parameters, LV systolic dysfunction, and symptoms; however, emerging data suggest that there may be benefit of aortic valve replacement before it becomes severe by present criteria. Myocardial assessment using novel multimodality imaging techniques exhibits subclinical myocardial injury and remodeling at various stages before guideline-directed interventions, which predicts adverse outcomes. This raises the question of whether implementing serial myocardial assessment should become part of the standard appraisal, thereby identifying high-risk patients aiming to minimize adverse outcomes.
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http://dx.doi.org/10.1016/j.hfc.2023.05.010 | DOI Listing |
Discov Nano
September 2025
Department of Rehabilitation Medicine, Rehabilitation Medical Center, Key Laboratory of Rehabilitation Medicine in Sichuan Province, West China Hospital, Sichuan University, Chengdu, 610041, People's Republic of China.
Immunoelectron Microscopy (IEM) is a technique that combines specific immunolabeling with high-resolution electron microscopic imaging to achieve precise spatial localization of biomolecules at the subcellular scale (< 10 nm) by using high-electron-density markers such as colloidal gold and quantum dots. As a core tool for analyzing the distribution of proteins, organelle interactions, and localization of disease pathology markers, it has irreplaceable value, especially in synapse research, pathogen-host interaction mechanism, and tumor microenvironment analysis. According to the differences in labeling sequence and sample processing, the IEM technology system can be divided into two categories: the first is pre-embedding labeling, which optimizes the labeling efficiency through the pre-exposure of antigenic epitopes and is especially suitable for the detection of low-abundance and sensitive antigens; the second is post-embedding labeling, which relies on the low-temperature resin embedding (e.
View Article and Find Full Text PDFJACC Case Rep
September 2025
Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.
Background: Cardiac sarcoidosis (CS) usually affects the left ventricle and presents with nonspecific features like conduction abnormalities and ventricular arrhythmias. However, right ventricle (RV)-dominant involvement has been increasingly reported, making diagnosis difficult.
Case Summary: A 55-year-old man presented with palpitations.
Radiology
September 2025
Department of Biomedical Informatics, Harvard Medical School, 10 Shattuck St, Boston, MA 02115.
Despite the rapid growth of Food and Drug Administration-cleared artificial intelligence (AI)- and machine learning-enabled medical devices for use in radiology, current tools remain limited in scope, often focusing on narrow tasks and lacking the ability to comprehensively assist radiologists. These narrow AI solutions face limitations in financial sustainability, operational efficiency, and clinical utility, hindering widespread adoption and constraining their long-term value in radiology practice. Recent advances in generative and multimodal AI have expanded the scope of image interpretation, prompting discussions on the development of generalist medical AI.
View Article and Find Full Text PDFJMIR Form Res
September 2025
Department of Critical Care Medicine, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangdong Provincial Geriatrics Institute, No. 106, Zhongshaner Rd, Guangzhou, 510080, China, 86 15920151904.
Background: Point-of-care ultrasonography has become a valuable tool for assessing diaphragmatic function in critically ill patients receiving invasive mechanical ventilation. However, conventional diaphragm ultrasound assessment remains highly operator-dependent and subjective. Previous research introduced automatic measurement of diaphragmatic excursion and velocity using 2D speckle-tracking technology.
View Article and Find Full Text PDFTop Magn Reson Imaging
October 2025
BIOSPACE LAB, Nesles-la-Vallée, France.
Aims: Cardiac tumors are aggressive and asymptomatic in early stages, causing late diagnosis and locoregional metastasis. Currently, the standard of care uses gadolinium-based contrast agents for MRI, and the associated hypersensitivity reactions are a significant concern, such as gadolinium deposition disease. In addition, the proximity of cardiac lesions closer to vital structures complicates surgical interventions.
View Article and Find Full Text PDF