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This article presents the structured H design and validation of two types of flight controller architectures: a passive fault-tolerant controller for the longitudinal motion and an active observer-based fault-tolerant controller for the lateral-directional motion. In the first, the controller follows the conventional Stability/Control Augmentation System (SCAS) structure, and its gains are obtained in continuous-time with the hinfstruct command by considering a set of elevator Loss-Of-Efficiency (LOE) faults. For the second, the conventional Luenberger observer-based controller structure is used, and the design aims to monitor the health of the aileron and rudder actuators in addition to provide active tolerance against LOE faults. Two different discrete-time designs are obtained for the latter, one focused on control performance optimization (using also the hinfstruct command), and the other on simultaneous control and observer performance optimization (using the systune command and under a slightly relaxed control performance constraint). For the two types of architectures, unmodeled dynamics are represented by uncertain bounded time delays modeled as pure delays or first-order Padé approximations. The resulting controllers are implemented on-board JAXA's research airplane MuPAL-α, and not only is their practicality demonstrated but also control performance is validated via Aircraft-In-the-Loop (AIL) testing under gust-free and realistic gusty conditions. This demonstration is at a Technological Readiness Level (TRL) of 7-8, resulting in a high-level of confidence in the validity of the proposed flight control structures.
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http://dx.doi.org/10.1016/j.isatra.2023.08.029 | DOI Listing |
Alzheimers Res Ther
September 2025
Department of Neurology, Saarland University, Kirrberger Straße, 66421, Homburg/Saar, Germany.
Background: Alzheimer's disease (AD) patients and animal models exhibit an altered gut microbiome that is associated with pathological changes in the brain. Intestinal miRNA enters bacteria and regulates bacterial metabolism and proliferation. This study aimed to investigate whether the manipulation of miRNA could alter the gut microbiome and AD pathologies.
View Article and Find Full Text PDFInfect Dis Poverty
September 2025
Faculty of Medicine and Pharmaceutical Sciences, University of Douala, Douala, Cameroon.
Background: Little is documented on key community-based One Health (OH) approach implementation, pro-activeness and effectiveness of interactions and strategies against Mpox outbreak public health emergency in international concern (PHEIC) in various African countries in order to stamp out the persisting Mpox outbreak threat and burden. Prioritizing critical community-based interventions and lessons learned from previous COVID-19, Mpox, Ebola, COVID-19, Rift Valley Fever and Marburg virus outbreaks revealed critical shortcomings in funding, surveillance, and community engagement that plague public health initiatives across the continent. The article provides critical insights and benefits of community-based One Health approaches implementation against Mpox outbreak management in Africa.
View Article and Find Full Text PDFBMC Vet Res
September 2025
Veterinary Internal Medicine, Department of Animal Medicine, Faculty of Veterinary Medicine, Assiut University, Assiut, 71526, Egypt.
Background: Disturbances in lipid metabolism are usually associated with hyperlipidemia, which is commonly observed in donkeys with inappetence or anorexia. The diagnostic utility of ultrasound measurements of croup fat thickness (CFT) and relative liver echogenicity for lipomobilization in donkeys with fasting-induced hyperlipidemia was investigated. A prospective observational control study involving 25 donkeys was conducted, and the animals were randomly assigned to a fasting group (FG, n = 20) and a control group (CG, n = 5).
View Article and Find Full Text PDFBMC Pediatr
September 2025
Department of Pediatrics, Faculty of Medicine, Tanta University, Tanta, Egypt.
Background: This study aimed to evaluate the impact of asthma severity on biventricular cardiac functions using tissue Doppler imaging (TDI), two-dimensional speckle tracking echocardiography (2D-STE), and three-dimensional speckle tracking echocardiography (3D-STE).
Methods: Sixty-three children with asthma, aged between 5 and 16 years, were enrolled in the study along with 63 matched controls. All participants underwent cardiac assessments, including TDI, 2D-STE, 3D-STE, conventional echocardiography, and pulmonary function testing with spirometry.
J Mol Neurosci
September 2025
Department of Physiology, School of Medicine, Dokuz Eylul University, Izmir, Turkey.
The ketogenic diet (KD), a high-fat, low-carbohydrate regimen, has been shown to exert neuroprotective effects in various neurological models. This study explored how KD-alone or combined with antibiotic-induced gut microbiota depletion-affects cognition and neuroinflammation in aging. Thirty-two male rats (22 months old) were assigned to four groups (n = 8): control diet (CD), ketogenic diet (KD), antibiotics with control diet (AB), and antibiotics with KD (KDAB).
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