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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10624615PMC
http://dx.doi.org/10.1038/s41375-023-02016-6DOI Listing

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Impact of secondary-type mutations on the prognosis of AML patients with NPM1 mutation: a systematic review and meta-analysis.

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Department of Hematology and Institute of Hematology, West China Hospital, Sichuan University, Chengdu, 610041, PR China.

Nucleophosmin 1 (NPM1) mutation is commonly associated with a favorable prognosis in acute myeloid leukemia (AML). Conversely, secondary mutations such as those in ASXL1, RUNX1, EZH2, and SRSF2 are generally linked to poor outcomes. The combined prognostic impact of NPM1 and secondary mutations in AML patients remains unclear.

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