Innovative margin design and optimized isocenter to minimize the normal tissue in target volumes for single-isocenter multi-target stereotactic radiosurgery.

Treating multiple brain metastases in a single plan is a popular radiosurgery technique. However, targets positioned off-isocenter are subject to rotational uncertainties. This work introduces two new planning target volumes (PTVs) that address this increased uncertainty. The volume of normal tissue included in these PTVs when paired with optimized isocenters are evaluated and compared with conventional methods.Sets of 1000 random multi-target radiosurgery patients were simulated, each patient with a random number of spherical targets (2-10). Each target had a random volume (0.1-15 cc) and was randomly positioned between 5 and 50 mm or 100 mm from isocenter. Two new PTVs ('LensPTV' and 'SwipePTV') and conventional isotropic PTVs were created using isocenters derived from the center-of-centroids, the center-of-mass, or optimized per PTV type. The total volume of normal tissue in the PTVs for each patient was calculated and compared using 1 mm translations and 0.5°, 1.0°, and 2.0° rotations.Using the new PTVs and/or using optimized isocenters decreased the total volume of normal tissue in the PTVs per patient. The SwipePTV, in particular, provided the greatest decrease. Compared to the SwipePTV, the LensPTV and the conventional isotropic PTV included an extra 0.68 and 0.73 cc of normal tissue per patient (median), respectively, when using 50 mm max distance to isocenter and 1° max rotation angle. Under these conditions, 25% of patients had extra volume of normal tissue ≥ 0.96 and 1.04 cc. When using 100 mm max distance to isocenter and 2° max rotation angle, 25% of patients had extra volume of normal tissue ≥ 4.35 and 5.75 cc.PTVs like those presented here, especially when paired with optimized isocenters, can decrease the total volume of included normal tissue and reduce the risk of toxicity without compromising target coverage.