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Introduction: In this clinical trial, we investigated the efficacy of two treatment methods for keloids resulting from surgical incisions: intralesional triamcinolone injections alone versus in combination with verapamil.
Material And Methods: Patients were divided into two groups: one received triamcinolone alone (Group T) and the other received a triamcinolone-verapamil blend (Group VT). Regular treatments were conducted until the keloids were nearly flat or for a maximum of eight sessions.
Results: Both groups showed significant improvements, but Group VT saw quicker resolution of skin redness and needed fewer sessions. Though the Vancouver Scar Scale (VSS) scores were generally similar across both groups, Group VT exhibited greater improvements, leading to lower final scores. The VT group also attained normal scar flexibility faster than the T group.
Conclusion: These findings suggest that the combination of verapamil and triamcinolone provides a more effective treatment for keloids, thereby highlighting the potential of verapamil in scar reduction.
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http://dx.doi.org/10.1111/iwj.14314 | DOI Listing |
Clin Cosmet Investig Dermatol
September 2025
Department of Dermatology and Venereology, Faculty of Medicine, Universitas Padjadjaran-Dr. Hasan Sadikin Hospital, Bandung, Indonesia.
Background: Keloids are fibroproliferative disorders characterized by excessive scarring, functional impairment, and aesthetic concerns. Despite the availability of various treatments, recurrence rates remain high, highlighting the need for alternative therapies with favorable safety profiles. Botulinum toxin A (BTX-A) has emerged as a potential option for keloid treatment; however, its therapeutic role is still not fully elucidated.
View Article and Find Full Text PDFJ Pediatr Surg
August 2025
Department of Pediatric Colorectal & Pelvic Reconstructive Surgery, Nationwide Children's Hospital, Columbus, OH, USA. Electronic address:
Purpose: Anastomotic stricture leads to significant post-operative morbidity for patients with anorectal malformations (ARM) and Hirschsprung Disease (HSCR). The injection of the long-acting steroid triamcinolone acetonide (TAC) after stricture dilation has been shown to decrease stricture recurrence and interventions needed to achieve resolution but has yet to be studied in patients with ARM or HSCR.
Methods: We performed a single-institution retrospective review of patients with ARM or HSCR who underwent TAC injection with dilation for anastomotic stricture.
Burns
August 2025
Department of Dermatology, Venereology & Leprosy, Patna Medical College & Hospital, Bihar, India.
Background: For many burn survivors, the symptomatic burn scarring can limit the functionality and compromise the quality of life. Various modalities have been in use over the years to minimize the scar-related distress of the patients but none effective in totality. Due to availability of sparse data on efficacy of a most potent combination therapy, we used split-scar technique to compare Er:YAG and triamcinolone versus triamcinolone alone.
View Article and Find Full Text PDFIndian Dermatol Online J
September 2025
Department of Dermatology, Venereology and Leprosy, Tirunelveli Medical College and Hospital, Tamil Nadu, India.
Background: Keloids are benign overgrowth of fibrous tissue extending beyond the original wound margin. The management of keloids remains challenging despite the various treatments available. Studies have shown that combination therapies are superior to monotherapy.
View Article and Find Full Text PDFItal J Dermatol Venerol
August 2025
Dermatology Unit, S.A. Abate Hospital, Trapani, Italy.