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Article Abstract
This study examined the usefulness of H T relaxation measurements for evaluating the homogeneity of amorphous solid dispersion (ASD). Indomethacin and polyvinylpyrrolidone were used to prepare two kinds of ASDs. One was inhomogeneous ASD (ASD) prepared by a melt-quenching method, and the other was homogeneous ASD (ASD) prepared by a solvent evaporation method. The T relaxation was measured by the time-domain NMR (TD-NMR) technique using a low-field NMR system. Curve-fitting analysis of T relaxation plots was conducted using the Akaike information criterion. This fitting analysis revealed that the T relaxation of ASD and ASD was biphasic and monophasic, respectively. ASD and ASD were inhomogeneous and homogeneous on a nanometer scale, respectively, considering the spin diffusion of H nuclei. These T results were consistent with the Raman mapping of ASDs. From the fitting analysis of H T relaxation, we conclude that TD-NMR is a promising technique for evaluating ASD homogeneity.
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| http://dx.doi.org/10.1016/j.xphs.2023.08.021 | DOI Listing |
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