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Background: COVID-19 has resulted in significant disability and loss of life. COVID-19 vaccines effectively prevent severe illness, hospitalization, and death. Nevertheless, many people remain hesitant to accept vaccination. Veterans perceive healthcare providers (HCP) and staff as trusted vaccine information sources and thereby are well suited to initiate vaccine discussions. The overall objective of this study is to implement and test a virtual COVID-19 Vaccine Acceptance Intervention (VAI) training that is informed by motivational interviewing (MI) techniques.
Methods: The VAI training is being delivered to VA HCPs and staff within a Hybrid Type 2 pragmatic implementation-effectiveness trial using Implementation Facilitation as the implementation strategy. The implementation team includes external facilitators paired with VA Healthcare System (VAHCS)-level internal facilitators. The trial has three aims: 1) Examine the effectiveness of the VAI versus usual care on unvaccinated veterans' vaccination rates in a one-year cluster randomized controlled trial, with randomization at the level of VAHCS. 2) Determine factors associated with veterans' decisions to accept or decline primary COVID-19 vaccination, and better understand how these factors influence vaccination decisions, through survey and qualitative data; and 3) Use qualitative interviews with HCPs and staff from clinics with high and low vaccination rates to learn what was helpful and not helpful about the VAI and implementation strategies.
Conclusion: This is the first multisite randomized controlled trial to test an MI-informed vaccine acceptance intervention to improve COVID-19 vaccine acceptance. Information gained can be used to inform healthcare systems' approaches to improve future vaccination and other public health campaigns.
Clinicaltrials: gov Identifier: NCT05027464.
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http://dx.doi.org/10.1016/j.cct.2023.107325 | DOI Listing |
J Med Internet Res
September 2025
School of Nursing, University of Minho, Braga, Portugal.
Background: The spread of misinformation on social media poses significant risks to public health and individual decision-making. Despite growing recognition of these threats, instruments that assess resilience to misinformation on social media, particularly among families who are central to making decisions on behalf of children, remain scarce.
Objective: This study aimed to develop and evaluate the psychometric properties of a novel instrument that measures resilience to misinformation in the context of social media among parents of school-age children.
Background: People with dementia who have a fall can experience both physical and psychological effects, often leading to diminished independence. Falls impose economic costs on the healthcare system. Despite elevated fall risks in dementia populations, evidence supporting effective home-based interventions remains limited.
View Article and Find Full Text PDFNeurol Sci
September 2025
Pediatric Neurosurgery Unit, IRCCS Istituto Giannina Gaslini, Genoa, Italy.
Background: super-refractory status epilepticus (SRSE) is a rare and severe neurological condition associated with high mortality and significant long-term morbidity. In many cases, conventional medical treatments prove ineffective, with wide use of off-label therapies.
Methods: two researchers conducted a review of the medical records of subjects who had undergone VNS implantation in our tertiary Centre.
Clin Res Cardiol
September 2025
Department of Cardiology, University Heart Center, University Hospital Zurich, Center for Translational and Experimental Cardiology (CTEC), University of Zurich, Rämistrasse 100, 8091, Zurich, Switzerland.
Background: Diabetic patients with ST-segment elevation myocardial infarction (STEMI) are at an increased risk of cardiovascular events as compared to non-diabetic patients. This analysis investigated outcomes of diabetic patients presenting with multivessel disease (MVD) and STEMI in a contemporary trial and the relevance of an immediate versus staged multivessel PCI strategy in this high-risk population.
Methods: Patients enrolled in the MULTISTARS AMI trial were stratified according to the presence/absence of diabetes.
Am J Orthod Dentofacial Orthop
September 2025
Department of Orthodontics, Faculty of Dentistry, Phenikaa University, Duong Noi, Hanoi, Vietnam.
Introduction: This study investigated the effect of sandblasting time and primer type on the shear bond strength of composite attachments to full-contour zirconia crowns.
Methods: A total of 108 zirconia specimens were fabricated and divided into 9 groups (n = 12) according to sandblasting time (10, 30, and 60 seconds) and primer type (silane, 10-methacryloyloxydecyl dihydrogen phosphate [MDP], universal). After sandblasting with 110-μm alumina particles, specimens were primed, and attachments were bonded using a packable composite.