Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Objective: To analyze age-related changes in the choroid in healthy eyes using swept-source optical coherence tomography angiography (SS-OCTA).
Patients And Methods: This was a cross-sectional, prospective, observational study enrolling 222 eyes of 116 healthy participants. SS-OCTA images were captured using the PLEX Elite 9000 (Carl Zeiss Meditec) with a 6 x 6 mm pattern centered on the fovea. Subfoveal choroidal thickness (CT) and choroidal volume (CV) were generated automatically through manufacturer tools available in the Advanced Retinal Imaging (ARI) hub network. Choroidal vascularity index (CVI) and choriocapillaris flow deficits (CCFD) were computed using ImageJ.
Results: CV was found to be significantly higher in women than men. Overall, there was a significant positive correlation between CVI and CCFD, and a significant negative correlation between CT and CV with age. The relationship, however, was more complex, as a decade-wise analysis showed that CT and CV increased until the second decade, followed by a decrease until the sixth decade, and then an increase again in the seventh and eighth decades. CVI was highest in the seventh decade. In contrast, CCFD increased consistently with age and in all the Early Treatment of Diabetic Retinopathy Study (ETDRS) rings.
Conclusion: The choroidal blood flow and its thickness reduces as the age advances. While the choroidal flow deficits show a consistent increase with age and the distance from the foveal center, the relationship of other parameters with age is more complex. Having a normative database from healthy subjects is imperative for understanding the changes taking place in diseased states. Choroidal parameters can show significant variations with age. These differences are not uniform or consistent with age, highlighting the importance of a normative reference database to assess the significance of choroidal alterations associated with disease. .
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.3928/23258160-20230728-01 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Quantification of Normative Human Choriocapillaris Measures Across the Macula.
Invest Ophthalmol Vis Sci
September 2025
Division of Biomedical Physics, Office of Science and Engineering Laboratories, Center for Devices and Radiological Health, U.S. Food and Drug Administration, Silver Spring, Maryland, United States.
Purpose: To assess macular choriocapillaris (CC) metrics in healthy volunteers (HVs) without ocular disease and demonstrate CC variations in patients with inherited retinal dystrophies (IRDs) using adaptive optics optical coherence tomography angiography (AO-OCTA).
Methods: Twenty-one HVs and three IRD patients were imaged. Macular variation in 20 HVs in CC metrics (CC density, CC diameter, CC tortuosity, void diameter, void area, lobule count, lobule area, and RPE-CC distance) were assessed by imaging a 28° strip of overlapping AO-OCTA volumes (3° × 3°) from the optic nerve head to the temporal macula.
Three-Dimensional Choroidal Vessels Assessment in Fellow Eyes of Patients With Central Serous Chorioretinopathy.
Transl Vis Sci Technol
September 2025
Department of Ophthalmology, University of Pittsburgh, School of Medicine, Pittsburgh, Pennsylvania, USA.
Purpose: To evaluate choroidal vasculature using a novel three-dimensional algorithm in fellow eyes of patients with unilateral chronic central serous chorioretinopathy (cCSC).
Methods: Patients with unilateral cCSC were retrospectively included. Automated choroidal segmentation was conducted using a deep-learning ResUNet model.
Choroidal Vascularity Index as a marker of health and disease: Systematic review and meta-Analyses.
Surv Ophthalmol
September 2025
Yong Loo Lin School of Medicine, National University of Singapore, Singapore; National Healthcare Group Eye Institute, Tan Tock Seng Hospital, Singapore; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore; Programme for Ocular Inflammation & Infection Translational Resear
The Choroidal Vascularity Index (CVI), derived from optical coherence tomography (OCT), has emerged as a potential biomarker for detecting vascular changes. Understanding its variability across physiological states, ocular conditions, and systemic diseases is crucial for its integration into clinical practice. We evaluated variations in CVI across different physiological states (e.
View Article and Find Full Text PDFCompensatory retinal blood flow enhancement in cognitively normal ApoE ε4 carriers.
Sci Rep
September 2025
Department of Neurology, The First Affiliated Hospital With Nanjing Medical University, Nanjing, 210029, China.
This study aims to compare retinal vascular characteristics between ApoE ε4 carriers and non-carriers in healthy individuals. A total of 84 cognitively healthy subjects-64 non-carriers and 20 carriers of the ApoE ε4 allele-were analyzed using swept-source optical coherence tomography angiography (SS-OCTA). In the retinal vascular layer of OCTA images, parameters such as foveal avascular zone (FAZ) area, vessel perimeter, acircularity index (AI), and vascular density (FD) were quantified.
View Article and Find Full Text PDFThe effect of diabetes mellitus to retinal vascularity in patients without diabetic retinopathy.
Clin Exp Optom
September 2025
Department of Ophthalmology, Ege University, Izmir, Turkey.
Clinical Relevance: Understanding early microvascular alterations in the retinal and choroidal structures of patients with diabetes mellitus is essential for the timely identification of high-risk individuals and the prevention of vision-threatening complications.
Background: This study evaluates the impact of diabetes mellitus (DM) on retinal and choroidal vascular structures using optical coherence tomography angiography (OCTA) in pre-retinopathic patients. It also explores the relationship between OCTA parameters and HbA1c levels, a marker of long-term glycaemic control.