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http://dx.doi.org/10.4103/0028-3886.383866 | DOI Listing |
Hidden within host cells, the endosymbiont is the most prevalent bacterial infection in the animal kingdom. Scientific breakthroughs over the past century yielded fundamental mechanisms by which controls arthropod reproduction to shape dynamic ecological and evolutionary trajectories. However, the structure and spatial organization of symbiont machineries that underpin intracellular colonization and orchestrate maternal inheritance remain unknown.
View Article and Find Full Text PDFSci Adv
September 2025
Coastal & Ocean Studies Program of Williams College & Mystic Seaport, Mystic, CT 06355, USA.
The burgeoning abundance of a microscopic marine invader on the US Atlantic seaboard may signal the scale of overlooked non-native species in the sea.
View Article and Find Full Text PDFExplor Target Antitumor Ther
August 2025
Women's Biomedical Research Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
O-Methylguanine-DNA methyltransferase (MGMT) acts as a genomic custodian, reversing alkylation damage to preserve DNA integrity. However, when its regulatory balance tips via promoter methylation, polymorphisms, or epigenetic silencing, MGMT can become a liability, fuelling cancer progression, treatment resistance, and poor outcomes across malignancies. This review uncovers the nuanced control of MGMT, revealing how its genetic and epigenetic shifts shape tumor behavior, therapeutic response, and risk stratification.
View Article and Find Full Text PDFGenome structural variants (SVs) comprise a sizable portion of functionally important genetic variation in all organisms; yet, many SVs evade discovery using short reads. While long-read sequencing can find the hidden SVs, the role of SVs in variation in organismal traits remains largely unclear. To address this gap, we investigate the molecular basis of 50 classical phenotypes in 11 strains using highly contiguous genome assemblies generated with Oxford Nanopore long reads.
View Article and Find Full Text PDFPLoS One
September 2025
HumanEra, Research and Innovation, North York General Hospital, Toronto, Ontario, Canada.
Due to a lack of safeguards, controlled substances (CS) can be diverted (stolen) from healthcare facilities. While it is known that healthcare workers (HCWs) can use their social networks within the medication use process (MUP) to facilitate diversion, the specific connections between HCWs and the MUP tasks most vulnerable to diversion remain poorly understood. Social network analysis (SNA) was used to analyze social connections to identify influential relationships between HCWs and tasks susceptible to diversion.
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