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http://dx.doi.org/10.1016/j.resuscitation.2023.109947 | DOI Listing |
ISA Trans
September 2025
School of Mechatronic Engineering, Jiangsu Normal University, Xuzhou 221116, China. Electronic address:
Multi-arm rock drilling robots frequently encounter challenges in extreme environments, such as tunnels, where they are subjected to high-frequency impact loads, multi-degree-of-freedom motion coupling, and large-range motion control vibrations. First, we propose a collision-free path planning method that combines an improved genetic algorithm (IGA) and an improved artificial potential field method. This method is based on the kinematic model of the rock drilling robot.
View Article and Find Full Text PDFPLoS One
September 2025
College of Business Administration, Seoul National University, Seoul, South Korea.
This study investigates the relationship between occupational automation risks and workers' transitions to entrepreneurship using data from the Current Population Survey. We find that employees facing automation-related job displacement are inclined to shift toward unincorporated entrepreneurship, emphasizing entrepreneurship as a viable alternative career path. Noteworthy variations emerge when examining specific automation technologies, revealing a positive association between industrial robots and entrepreneurial transitions, whereas artificial intelligence displays a negative relationship.
View Article and Find Full Text PDFIEEE Trans Comput Biol Bioinform
September 2025
Artificial intelligence (AI) based anticancer drug recommendation systems have emerged as powerful tools for precision dosing. Although existing methods have advanced in terms of predictive accuracy, they encounter three significant obstacles, including the "black-box" problem resulting in unexplainable reasoning, the computational difficulty for graphbased structures, and the combinatorial explosion during multistep reasoning. To tackle these issues, we introduce a novel Macro-Micro agent Drug sensitivity inference (MarMirDrug).
View Article and Find Full Text PDFNEJM AI
September 2025
Department of Biomedical Informatics, Harvard Medical School, Boston.
Over the past two decades, network medicine (NM) has evolved to help define disease mechanisms, identify drug targets, and guide increasingly precise therapies. In recent years, the integration of NM with artificial intelligence (AI), particularly deep learning techniques, has evolved with increasing applications. AI techniques help elucidate complex disease mechanisms and define precise therapies.
View Article and Find Full Text PDFFront Biosci (Landmark Ed)
August 2025
Department of Integrated Applied Life Science, Integrated Graduate School of Medicine, Engineering, and Agricultural Sciences, University of Yamanashi, 400-8510 Yamanashi, Japan.
Background: Lysosomes serve not only in the degradation of cellular components but also as calcium (Ca) stores. In this study, we investigated the effects of trans-Ned19, an inhibitor of lysosomal calcium channels known to block two-pore channels (TPCs), on fertilization and oocyte activation in mice.
Methods: Pronuclear formation was assessed via Hoechst 33342 staining, cortical granule release was evaluated using agglutinin-fluorescein isothiocyanate (LCA-FITC) staining, intracellular Ca levels were monitored with Cal-520 AM, and sperm motility was analyzed using a sperm motility analysis system (SMAS).