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Previous research has shown that some forms of non-invasive brain stimulation can increase fatigue resistance. The purpose of this study is to determine the influence of transcranial alternating current stimulation (tACS) on the time to task failure (TTF) of a precision grip task. The study utilized a randomized, double-blind, SHAM-controlled, within-subjects design. Twenty-six young adults completed two experimental sessions (tACS and SHAM) with a 7-day washout period between sessions. Each session involved a fatiguing isometric contraction of the right hand with a precision grip with either a tACS or SHAM stimulation applied to the primary motor cortex (M1) simultaneously. For the fatiguing contraction, the participants matched an isometric target force of 20% of the maximum voluntary contraction (MVC) force until task failure. Pre- and post-MVCs were performed to quantify the force decline due to fatigue. Accordingly, the dependent variables were the TTF and MVC force decline as well as the average EMG activity, force error, and standard deviation (SD) of force during the fatiguing contractions. The results indicate that there were no significant differences in any of the dependent variables between the tACS and SHAM conditions ( value range: 0.256-0.820). These findings suggest that tACS does not increase the TTF during fatiguing contractions in young adults.
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http://dx.doi.org/10.3390/brainsci13081225 | DOI Listing |
Exp Brain Res
September 2025
Siena Brain Investigation and Neuromodulation Lab (Si-BIN Lab), Department of Medicine, Surgery and Neuroscience, Neurology and Clinical Neurophysiology Section, University of Siena, Siena, Italy.
Postdiction is a perceptual phenomenon where the perception of an earlier stimulus is influenced by a later one. This effect is commonly studied using the 'rabbit illusion', in which temporally regular, but spatially irregular, stimuli are perceived as equidistant. While previous research has focused on short inter-stimulus intervals (100-200 ms), the role of longer intervals, which may engage late attentional processes, remains unexplored.
View Article and Find Full Text PDFPLoS One
September 2025
Scientific Institute, IRCCS E. Medea, Bosisio Parini (LC), Italy.
Background: Children with cerebral palsy (CP) commonly face gross motor function impairments and manual dexterity deficits, significantly affecting their activity level and independence and, ultimately, quality of life. Rehabilitation often targets improving manual dexterity and activity levels, but standard therapies have limited efficacy. Hence, exploring novel methods to enhance upper limb functionality is crucial.
View Article and Find Full Text PDFJ Neural Eng
August 2025
Department of Communication Sciences and Disorders, Louisiana State University, LSU, Baton Rouge, 70803, UNITED STATES.
Objective: The supplementary motor area (SMA) demonstrates abnormal beta activity (13-30 Hz) during speech and limb movement tasks in neurological conditions such as Parkinson's disease (PD). Transcranial Alternating Current Stimulation (tACS) has demonstrated promising improvements in motor and non-motor functions by entraining endogenous neural oscillations. We conducted an exploratory study on the modulatory effects of personalized beta high-definition (HD)-tACS over the left SMA on speech production and limb movement.
View Article and Find Full Text PDFBrain Stimul
August 2025
Department of Neurophysiology and Pathophysiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Biomedical Signals and Systems, Electrical Engineering, Mathematics and Computer Science, University of Twente, Enschede, the Netherlands. Electronic address:
Background: Communication within brain networks depends on functional connectivity. One promising approach to modulate such connectivity between cortical areas is dual-site transcranial alternating current stimulation (tACS), which non-invasively applies weak alternating currents to two brain areas.
Objectives: In the current study, we aimed to modulate inter-regional functional connectivity with dual-site tACS to bilateral primary motor cortices (M1s) during bimanual coordination and, in turn, alter behaviour.
Biol Psychol
August 2025
Department of Cognitive Neuroscience, Faculty of Psychology and Neuroscience, Maastricht University, Maastricht, the Netherlands; Maastricht Brain Imaging Centre, Maastricht University, Maastricht, the Netherlands.
Executive cognitive functions are essential for human life, and their age- or disease-related decline significantly impacts quality of life. Non-invasive brain stimulation (NIBS) targeting the multiple-demand or fronto-parietal network (FPN) has emerged as a promising intervention for enhancing various executive cognitive functions. However, variations in cognitive tasks and stimulation protocols across studies led to mixed results, rendering findings and conclusions incomparable.
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