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One third of patients were colonized by Candida auris during a point-prevalence survey in a neonatal unit during an outbreak in South Africa. The sensitivity of a direct PCR for rapid colonization detection was 44% compared with culture. The infection incidence rate decreased by 85% after the survey and implementation of isolation/cohorting.
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http://dx.doi.org/10.3201/eid2909.230393 | DOI Listing |
Microb Genom
September 2025
Regional Innovative Public Health Laboratory, Rush University Medical Center, Chicago, IL 60612, USA.
emerged in Chicago, IL, USA, in 2016 and has since become endemic. We used whole-genome sequencing (WGS) of 494 isolates, epidemiologic metadata and patient transfer data to describe the transmission of among Chicago healthcare facilities between 2016 and 2021. In total, 99% of isolates formed a single clade IV phylogenetic lineage, suggesting a single introduction.
View Article and Find Full Text PDFmBio
September 2025
Department of Biology, Laboratory of Molecular Cell Biology, KU Leuven, Leuven, Flanders, Belgium.
Echinocandins, which target the fungal β-1,3-glucan synthase (Fks), are essential for treating invasive fungal infections, yet resistance is increasingly reported. While resistance typically arises through mutations in Fks hotspots, emerging evidence suggests a contributing role of changes in membrane sterol composition due to mutations. Here, we present a clinical case of () in which combined mutations in and , but not alone, appear to confer echinocandin resistance.
View Article and Find Full Text PDFJ Infect Dev Ctries
August 2025
Hospital Infection Control Committee, Adana City Training and Research Hospital, Adana, Türkiye.
Introduction: Candida auris is a yeast that has a high mortality rate in critically ill patients and is resistant to many antifungal agents enhancing its clinical importance. Our study identifies the risk factors for C. auris invasive infection, antifungal susceptibility, and outcomes.
View Article and Find Full Text PDFCureus
August 2025
Internal Medicine, King Fahad Specialist Hospital, Dammam, SAU.
Candidemia, a common hospital-acquired bloodstream infection, is associated with significant mortality, particularly in cases involving (). The Middle East, including Saudi Arabia, has seen an increasing number of invasive infections. This review examines the epidemiology, risk factors, antifungal susceptibility, clinical manifestations, and mortality associated with , based on published literature from Saudi Arabia.
View Article and Find Full Text PDFJ Infect Public Health
August 2025
Infection Control Center, Xiangya Hospital, Central South University, Changsha, Hunan Province 410008, China; National Clinical Research Center for Geriatric Disorders (XiangYa Hospital), Changsha, Hunan Province 410008, China; Superbugs and Multidrug Resistant Microbes Infection Control Research Ce
Background: On October 25, 2022, the World Health Organization (WHO) released its first Fungal Priority Pathogen List (FPPL), classifying Cryptococcus neoformans (C. neoformans), Candida auris (C. auris), Aspergillus fumigatus (A.
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