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Vitiligo is the most common depigmenting skin disorder. Given the ongoing development of new targeted therapies, it has become important to evaluate adequately the surface area involved. Assessment of vitiligo scores can be time consuming, with variations between investigators. Therefore, the aim of this study was to build an artificial intelligence system capable of assessing facial vitiligo severity. One hundred pictures of faces of patients with vitiligo were used to train and validate the artificial intelligence model. Sixty-nine additional pictures of facial vitiligo were then used as a final dataset. Three expert physicians scored the facial vitiligo on the same 69 pictures. Inter and intrarater performances were evaluated by comparing the scores between raters and artificial intelligence. Algorithm assessment achieved an accuracy of 93%. Overall, the scores reached a good agreement between vitiligo raters and the artificial intelligence model. Results demonstrate the potential of the model. It provides an objective evaluation of facial vitiligo and could become a complementary/alternative tool to human assessment in clinical practice and/or clinical research.
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http://dx.doi.org/10.1016/j.jid.2023.07.014 | DOI Listing |
An Bras Dermatol
August 2025
Service of Dermatology, Santa Casa de São Paulo, São Paulo, SP, Brazil. Electronic address:
Phenol, or carbolic acid, is an organic compound with caustic and antiseptic properties widely used in dermatology. Since its introduction as an antiseptic in the 19 century, its use has expanded to various areas of medicine, including the treatment of dermatological conditions such as vitiligo, warts, guttate leukoderma, hidradenitis suppurativa, angiosarcoma, acne scars, alopecia areata, onychocryptosis, and actinic keratoses. In deep peels, phenol stands out for its effectiveness in skin rejuvenation, promoting intense and sustained neocollagenesis, with unparalleled results.
View Article and Find Full Text PDFJ Dermatolog Treat
December 2025
Department of Dermatology, The Fourth Affiliated Hospital of Soochow University (Suzhou Dushu Lake Hospital; Medical Center of Soochow University), Suzhou, China.
Objective: To compare the efficacy and safety of oral corticosteroids and JAK inhibitors as adjunctive treatments following non-cultured epidermal cell suspension (NCES) transplantation in patients with stable vitiligo.
Methods: Data were collected from 12 patients with stable vitiligo who underwent NCES transplantation at the Fourth Affiliated Hospital of Soochow University between June 2023 and December 2024. Postoperatively, 36 lesions (from 7 patients) were treated with oral corticosteroids, and 34 lesions (from 5 patients) with upadacitinib, totaling 70 vitiligo lesions evaluated.
Dermatol Ther (Heidelb)
August 2025
Evidera, Wilmington, NC, USA.
Introduction: Patients with vitiligo experience high disease and psychosocial burden, and dissatisfaction with current treatment options, highlighting a need to understand the disease from a patient perspective. This study gathered insights from key opinion leaders (KOLs) and patient advocates on a conceptual disease model of vitiligo and gained patient perspectives through qualitative interviews on the disease burden and concepts important to patients with nonsegmental vitiligo (NSV), and what degree and anatomical location of repigmentation may constitute a meaningful change with treatment.
Methods: This cross-sectional, observational study involved virtual, semi-structured, qualitative interviews with expert KOLs treating patients with vitiligo, patient advocates, and patients diagnosed with NSV.
Vitiligo is a common pigment disorder of the skin resulting in destruction of melanocytes. Non-segmental vitiligo (NSV) is an autoimmune disorder. The etiopathogenesis of segmental vitiligo (SV) remains incompletely understood.
View Article and Find Full Text PDFActa Derm Venereol
August 2025
Faculty of Medicine, University of Granada, Granada, Spain; Department of Dermatology, Hospital Universitario Virgen de las Nieves, Granada, Spain; Biosanitary Research Institute ibs.GRANADA, Granada, Spain.
Vitiligo is a chronic autoimmune disease that profoundly affects patients' quality of life. A cross--sectional, observational study was conducted with 51 patients using self-administered questionnaires, with the aim to evaluate the impact of vitiligo on major life-changing decisions (MLCDs) as well as on stigmatization using a modified version of the Patient Unique Stigmatization Holistic tool in dermatology (PUSH-D) scale. Results showed that the most affected MLCDs were clothing choices, social interactions, and lifestyle changes.
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