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http://dx.doi.org/10.1007/s12664-023-01429-6 | DOI Listing |
BMC Pediatr
September 2025
Department of Neonatology, Zhangzhou Affiliated Hospital of Fujian Medical University, Zhangzhou, Fujian, China.
Background: Red blood cell (RBC) transfusion is a common intervention for anemia in preterm infants; however, its association with bronchopulmonary dysplasia (BPD) remains debated. While biological mechanisms suggest potential harm, the clinical impact of transfusion frequency on BPD incidence and severity remains unclear.
Objective: To investigate whether RBC transfusion frequency is independently associated with the risk and severity of BPD in preterm infants born before 32 weeks of gestation.
Perfusion
September 2025
Department of Critical Care, King Fahad Medical City, Riyadh, Saudi Arabia.
Extracorporeal membrane oxygenation (ECMO) supports patients with severe refractory cardiac or respiratory failure but managing residual circuit blood after weaning lacks consensus. After decannulation, the oxygenator and circuit retain approximately 500-700 mL of blood, depending on tubing length, cannula size, and circuit configuration. Clinicians usually choose among direct reinfusion, cell-salvage processing, or disposal.
View Article and Find Full Text PDFBlood Vessel Thromb Hemost
August 2025
Department of Intensive Care, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
Transfusion-associated circulatory overload (TACO) is a leading cause of transfusion-associated mortality. TACO is thought to result from hydrostatic forces in the vascular space, leading to transudative pulmonary edema. Recent studies suggest that TACO is not solely a volume overload phenomenon, but may involve inflammatory processes.
View Article and Find Full Text PDFSaudi Med J
August 2025
From the Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Shaqra University, Shaqra, Riyadh, Kingdom of Saudi Arabia.
Transfusion-related acute lung injury (TRALI) remains one of the most serious yet often overlooked complications of blood transfusion, contributing to significant morbidity and mortality worldwide. It manifests as acute respiratory distress and non-cardiogenic pulmonary edema within 6 hours of transfusion, requiring immediate recognition and intervention. However, diagnosing TRALI is complex, as its clinical presentation overlaps with other causes of acute lung injury, and its underlying mechanisms remain incompletely understood.
View Article and Find Full Text PDFCurr Opin Immunol
October 2025
Sanquin Blood Supply Foundation, Department Research, Amsterdam, the Netherlands; Amsterdam UMC location University of Amsterdam, Landsteiner Laboratory, Meibergdreef 9, Amsterdam, the Netherlands. Electronic address:
Transfusion-related acute lung injury (TRALI) is a life-threatening complication of blood transfusion, with mortality rates exceeding 40% in critically ill patients. Despite its clinical severity, TRALI pathogenesis remains unclear, leaving clinicians struggling to fully understand and manage it due to its unpredictable onset, complex causes, and lack of available treatments. Recent advances in experimental models, including in vitro, ex vivo, and in vivo models, have revealed novel mechanisms such as neutrophil extracellular trap formation, gut-microbiota crosstalk, and endothelial and neutrophil-derived reactive oxygen species, as well as some preclinical therapeutic advancements.
View Article and Find Full Text PDF