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Objective: Cognitive loss in older adults is a growing issue in our society, and there is a need to develop inexpensive, simple, effective in-home treatments. This study was conducted to explore the use of olfactory enrichment at night to improve cognitive ability in healthy older adults.
Methods: Male and female older adults ( = 43), age 60-85, were enrolled in the study and randomly assigned to an Olfactory Enriched or Control group. Individuals in the enriched group were exposed to 7 different odorants a week, one per night, for 2 h, using an odorant diffuser. Individuals in the control group had the same experience with amounts of odorant. Neuropsychological assessments and fMRI scans were administered at the beginning of the study and after 6 months.
Results: A statistically significant 226% improvement was observed in the enriched group compared to the control group on the Rey Auditory Verbal Learning Test and improved functioning was observed in the left uncinate fasciculus, as assessed by mean diffusivity.
Conclusion: Minimal olfactory enrichment administered at night produces improvements in both cognitive and neural functioning. Thus, olfactory enrichment may provide an effective and low-effort pathway to improved brain health.
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http://dx.doi.org/10.3389/fnins.2023.1200448 | DOI Listing |
Pestic Biochem Physiol
November 2025
Key Laboratory of Forest Disaster Warning and Control of Yunnan Province, Southwest Forestry University, Kunming 650224, China. Electronic address:
The cerambycid beetles are important components in the terrestrial ecosystem as they play a dual role in both degrading dying trees and killing healthy plants. The factors including human activity, habitat contraction, climate changes and pesticide use have been shaping the adaptation of beetles to host plants and the environment. As suggested in research on the functions of beetles' olfactory proteins, odorant binding proteins (OBPs) have been found to be involved in insecticide resistance other than chemoreception.
View Article and Find Full Text PDFVestn Otorinolaringol
September 2025
Medical Center ENT Plus LLC, Perm, Russia.
Unlabelled: The urgency of the problem of acute rhinosinusitis is determined by the scale of its prevalence, the tendency to prolonged course and chronization, and its active role in the formation of severe complications, which necessitates the search for new methods of diagnosis and treatment of this pathology. Assessment of the sense of smell in patients with acute rhinosinusitis is an important diagnostic criterion that allows assessing the severity of inflammation and the effectiveness of therapy.
Objective: To improve the results of treatment of acute rhinosinusitis through the use of Inflasinusans, taking into account the assessment of the clinical picture and olfactory function.
Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
August 2025
Department of Otolaryngology, the Seventh Affiliated Hospital of Sun Yat-sen University, Shenzhen 518107, China.
To investigate the transcriptomic signature of refractory nasal polyps (NP) after endoscopic sinus surgery. Tissue samples were collected from 36 patients with NP who underwent endoscopic sinus surgery at the Seventh Affiliated Hospital of Sun Yat-sen University and the First Affiliated Hospital of Sun Yat-sen University from January 2020 to December 2021. Raw sequencing data of normal nasal mucosa samples were downloaded from publicly available GEO database (Accession Number: GSE136825).
View Article and Find Full Text PDFComput Biol Chem
August 2025
Department of Pharmaceutical Sciences, School of Pharmacy and Physician Assistant Studies, University of Saint Joseph, West Hartford, CT 06117, USA. Electronic address:
Protein lipidation/delipidation affects protein functions, interactions, and membrane trafficking. Dysregulation of this process might lead to tissue disorganization, abnormal proliferation, migration, and poor prognosis in cancer. While dysregulation of lipidation/delipidation in neurons has been associated with several neurodegenerative diseases, its potential link to neuronal dysfunction in cancer patients remains unexplored.
View Article and Find Full Text PDFBrain Sci
August 2025
Quantitative Imaging and Analysis Laboratories, Radiology Department, Duke University Medical Center, Durham, NC 27710, USA.
Olfactory impairment has been proposed as an early marker for Alzheimer's disease (AD), yet the mechanisms linking sensory decline to genetic and environmental risk factors remain unclear. We aimed to identify early biomarkers and brain network alterations associated with AD risk by multimodal analyses in humanized APOE mice. We evaluated olfactory behavior, diffusion MRI connectomics, and brain and blood transcriptomics in mice stratified by APOE2, APOE3, and APOE4 genotypes, age, sex, high-fat diet, and immune background (HN).
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