Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Aging-related salivary gland degeneration usually causes poor oral health. Periductal fibrosis frequently occurs in the submandibular gland of the elderly. Transforming growth factor β1 (TGF-β1) is the primary driving factor for fibrosis, which exhibits an increase in the fibrotic submandibular gland tissue. This study aimed to investigate the effects of TGF-β1 on the human submandibular gland (HSG) cell secretory function and its influences on aquaporin 5 (AQP5) expressions and distribution. We found that TGF-β1 reduces the protein secretion amount of HSG and leads to the abundance alteration of 151 secretory proteins. Data are available via ProteomeXchange with the identifier PXD043185. The majority of HSG secretory proteins (84.11%) could be matched to the human saliva proteome. Meanwhile, TGF-β1 enhances the expression of COL4A2, COL5A1, COL7A1, COL1A1, COL2A1, and α-SMA, hinting that TGF-β1 possesses the potential to drive HSG fibrosis-related events. Besides, TGF-β1 also attenuates the AQP5 expression and its membrane distribution in HSGs. The percentage for TGF-β1-induced AQP5 reduction (52.28%) is much greater than that of the TGF-β1-induced secretory protein concentration reduction (16.53%). Taken together, we concluded that TGF-β1 triggers salivary hypofunction via attenuating protein secretion and AQP5 expression in HSGs, which may be associated with TGF-β1-driven fibrosis events in HSGs.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1021/acs.jproteome.3c00052 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Enhancing submandibular gland resection: A retrospective study on the efficacy of the ORBEYE 3D exoscope.
Oral Maxillofac Surg
September 2025
Department of Otolaryngology, Head and Neck Surgery, Kansai Medical University, Shinmachi 2-5-1, Hirakata-city, Osaka, Japan.
Purpose: For submandibular gland resection, conventional surgery with the naked eye remains the standard. With its excellent automatic focus and high magnification, the ORBEYE 3D exoscope enables precise submandibular gland resection with less stress. Therefore, we aimed to examine the usefulness of the exoscope in submandibular gland resection.
View Article and Find Full Text PDFRole of Mesenchymal Stem Cell Exosomes and Injectable Platelet Rich Fibrin on Structure and Function of Submandibular Salivary Gland of Aged Albino Rats.
Saudi Dent J
September 2025
Oral Biology Department, Faculty of Dentistry, Ain Shams University, Cairo, Egypt.
To compare the efficacy of using bone marrow mesenchymal stem cell (BM-MSC) exosomes and injectable platelet rich fibrin (i-PRF) on the submandibular salivary glands (SMGs) of aged albino rats in restoring salivary gland structure and function. A total of 40 healthy male albino rats were used, two for obtaining the BM-MSCs, 10 for i-PRF preparation and seven adult rats (6-8 months old) represented the control group (Group 1). The remaining 21 rats were aged (18-20 months old) and divided into three groups of seven rats each; (Group 2): received no treatment, (Group 3): each rat received a single intraglandular injection of BM-MSC exosomes (50 μg/kg/dose suspended in 0.
View Article and Find Full Text PDFTreatments to Avoid Ranula Recurrence: A Network Meta-Analysis.
J Oral Pathol Med
September 2025
Department of Pediatric Dentistry, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Background: Oral and plunging ranulas require effective treatment strategies to minimize recurrence; yet no consensus exists on the most effective approach.
Objectives: This systematic review evaluated several treatments for the recurrence of oral and plunging ranulas.
Methodology: A comprehensive search was conducted in five bibliographic databases and gray literature.
Myoepithelial Carcinoma Ex-Pleomorphic Adenoma Exposing a RET Germline Mutation: A Rare Genetic Event.
Head Neck Pathol
September 2025
Department of Laboratory Medicine and Pathology, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL, 32224, USA.
Myoepithelial carcinoma (MECA) is a malignant neoplasm composed exclusively of myoepithelial cells and accounts for less than 1% of all salivary gland tumors. Its diagnosis is often challenging due to histologic overlaps with benign lesions and its variable morphologic presentation. Although molecular profiling has emerged as a valuable tool in salivary gland tumor classification, the genetic landscape of MECA remains incompletely defined.
View Article and Find Full Text PDFIntermittent fasting preserves the function and histological structure but induces oxidative stress in the salivary glands of male Wistar rats.
J Nutr Biochem
September 2025
Multicentric Postgraduate Program in Physiological Sciences, SBFis, São Paulo State University (UNESP), School of Dentistry, Araçatuba, SP, Brazil; Department of Basic Sciences, São Paulo State University (UNESP), School of Dentistry, Araçatuba, SP, Brazil; Postgraduate Program in Sciences, Pedi
Studies indicate that dietary patterns influence the function and redox balance of salivary glands. This study examined the effects of intermittent fasting (IF) on the function, histological structure, and redox balance of the salivary glands. Twenty 12-weeks-old male Wistar rats were randomized into two groups: ad libitum (AL), with continuous access to water and chow, and IF, subjected to 24-hour fasting on alternate days for 12 weeks.
View Article and Find Full Text PDF