Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Rectal cancer (RC) is a gastrointestinal cancer with a poor prognosis. While some studies have shown metabolic reprogramming to be linked to RC development, it is difficult to define biomolecules, like lipids, that help to understand cancer progression and response to therapy. The present study investigated the relative lipid abundance in tumoral tissue associated with neoadjuvant therapy response using untargeted liquid chromatography-mass spectrometry lipidomics. Locally advanced rectal cancer (LARC) patients (n = 13), clinically staged as T3-4 were biopsied before neoadjuvant chemoradiotherapy (nCRT). Tissue samples collected before nCRT (staging) and afterwards (restaging) were analyzed to discover lipidomic differences in RC cancerous tissue from Responders (n = 7) and Non-responders (n = 6) to nCRT. The limma method was used to test differences between groups and to select relevant feature lipids from tissue samples. Simple glycosphingolipids and differences in some residues of glycerophospholipids were more abundant in the Non-responder group before and after nCRT. Oxidized glycerophospholipids were more abundant in samples of Non-responders, especially those collected after nCRT. This work identified potential lipids in tissue samples that take part in, or may explain, nCRT failure. These results could potentially provide a lipid-based explanation for nCRT response and also help in understanding the molecular basis of RC and nCRT effects on the tissue matrix.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10380823 | PMC |
| http://dx.doi.org/10.3390/ijms241411479 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Robotic versus laparoscopic total mesorectal excision for mid-low rectal cancer after neoadjuvant chemoradiotherapy: a systematic review and meta-analysis of oncological, perioperative, and survival-related outcomes.
J Robot Surg
September 2025
Department of Oncology, Shengli Oilfield Central Hospital, Dongying, China.
A major cause of cancer death, colorectal cancer is becoming more common in younger people. The comparative effectiveness of robotic versus laparoscopic total mesorectal excision (TME) as surgical interventions for mid-low rectal cancer following neoadjuvant chemoradiotherapy (nCRT) remains uncertain. To systematically evaluate oncological, perioperative, and survival outcomes of robotic versus laparoscopic surgery for mid-low rectal cancer following nCRT.
View Article and Find Full Text PDFQuantitative blood perfusion assessment by the SPY-QP software program for minimally invasive rectal cancer surgery.
Surg Endosc
September 2025
Department of Colorectal Surgery, Kansai Medical University, 2-5-1, Shinmachi, Hirakata, Osaka, 573-1010, Japan.
Background: Although the usefulness of indocyanine green fluorescence imaging (ICG-FI) for anastomotic perfusion has been demonstrated in randomized controlled trials, the incidence of anastomotic leakage is not sufficiently low, even in patients using ICG. Because blood flow assessment using ICG is not completely objective, the objectivity of blood flow evaluation is expected to improve by quantification of fluorescence signals. This study aimed to clarify the efficacy of quantitative assessment of blood flow using ICG-FI with the SPY-QP software program in rectal cancer surgery.
View Article and Find Full Text PDFModification of the vascular preparation after high tie ligation to improve colonic perfusion and increase the length of the colon limb in low anterior rectal resection.
Surg Endosc
September 2025
Department of Surgery, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität, Campus Virchow Klinikum, Campus Charité Mitte, Augustenburger Platz 1, 13353, Berlin, Germany.
Introduction: High tie ligation of the inferior mesenteric artery (IMA) is the standard technique in oncological low anterior rectal resection. However, high tie may reduce blood flow to the colon, impairing distal tissue perfusion, anastomotic healing, and potentially causing necrosis. Therefore, a modified high tie technique (MoHiTi) was developed that preserves the arterial arc from the left colic artery via the proximal IMA to the first sigmoidal branch.
View Article and Find Full Text PDFIntroduction: Precise prediction of pathological complete response (pCR) following neoadjuvant chemoradiotherapy (nCRT) in rectal cancer may identify candidates for non-operative management. The optimal selection of diagnostic tools is therefore of major clinical importance.
Methods: Clinical, laboratory, endoscopic and radiological data of patients with rectal cancer treated with nCRT and surgery at an academic medical center from 2010 to 2020 were retrospectively collected.
Two Levels of High Ligation of the Inferior Mesenteric Artery Based on Three Anatomical Fasciae for Colorectal Cancer (with Video).
Ann Surg Oncol
September 2025
Department of Colorectal Surgery, Tianjin Union Medical Center, The First Affiliated Hospital of Nankai University, Tianjin, China.
Background: The ligation of the inferior mesenteric artery (IMA) is the primary procedure during surgeries of the left colon, sigmoid colon, and rectal cancer. Despite the ongoing debate on high or low ligation of the IMA, high ligation (HL) is now preferred by most of the surgeons. However, there is still a lack of consistency in the exact position of HL among surgical videos or introductions presented by different teams, causing confusion to new learners.
View Article and Find Full Text PDF