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http://dx.doi.org/10.1111/ejh.14045 | DOI Listing |
Radiat Res
August 2025
Department of Radiation Medicine, College of Naval Medicine, Naval Medical University, Shanghai, China.
High-energy neutron radiation (HENR) induces severe cellular and tissue damage, yet effective prophylactic agents remain limited. In this study, the TLR2/NOD2 co-agonist CL429 was evaluated for its radioprotective potential against 14.1 MeV neutron exposure.
View Article and Find Full Text PDFJ Infect Dis
September 2025
University of Veterinary Medicine Vienna, Infectiology, Vienna, Austria.
Frequent emergence of respiratory viruses with pandemic potential, like SARS-CoV-2 or influenza, underscores the need for broad-spectrum prophylaxis. Existing vaccines show reduced efficacy against newly emerged variants, and the ongoing risk of new outbreaks highlights the importance of alternative strategies to prevent infection and viral transmission. As respiratory viruses primarily enter through the nose, formulations targeting the nasal epithelium are attractive candidates to neutralize pathogens and thus prevent or minimize infection.
View Article and Find Full Text PDFIEEE J Biomed Health Inform
September 2025
This study aims to optimize the dynamic administration regimen of prophylactic enoxaparin in critically ill patients to reduce the risk of VTE, major bleeding, and 30-day all-cause mortality. We developed and internally and externally validated an artificial intelligence (AI) policy utilizing Double dueling deep Q network, using data from the Medical Information Mart for Intensive Care IV (MIMIC-IV) database (training and internal test set) and the eICU Collaborative Research Database (eICU-CRD, external test set). We compared the performance among the AI policy, the clinician's policy, the weight-tiered policy, and the fixed 40- mg-once-daily (QD) policy.
View Article and Find Full Text PDFJAMA Surg
September 2025
Department of Surgery, Meander Medical Center, Amersfoort, the Netherlands.
Importance: Stoma reversal is associated with few complications. However, recent studies show that 1 in 3 patients develop an incisional hernia, for which half of the patients receive surgical correction.
Objective: To investigate whether prophylactic synthetic mesh placement in the retromuscular space during stoma reversal reduces the rate of stomal site incisional hernias.
Vet World
July 2025
Latvia University of Life Sciences and Technologies, Faculty of Veterinary Medicine, Clinical Institute, Jelgava, LV-3004, Latvia.
Background And Aim: Gastrointestinal nematode infections have a significant impact on the health and productivity of sheep worldwide. Conventional anthelmintics are facing rising resistance, prompting the need for alternative control strategies. (tansy), a traditionally used antiparasitic herb in Latvia, has shown efficacy but lacks delivery validation.
View Article and Find Full Text PDF