Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Background: The severe neurologic tumor known as glioblastoma (GBM), also referred to as a grade IV astrocytoma, is rapidly progressive and debilitating. Supratotal resection (SpTR) is an emerging concept within glioma surgery, which aims to achieve a more extensive resection of the tumor than is possible with conventional techniques.
Methods: We performed a language-independent search of PubMed, Scopus, and Cochrane CENTRAL to identify all available literature up to August 2022 of patients undergoing SpTR assessing survival outcomes in comparison to other surgical modalities.
Results: After screening for exclusion, a total of 13 studies, all retrospective in design, were identified and included in our meta-analysis. SpTR was associated with significantly increased overall survival (hazard ratio 0.77, 95% CI 0.71-0.84; P < 0.01, I = 96%) and progression-free survival (hazard ratio 0.2, 95% CI 0.07-0.56; P = 0.002, I = 88%).
Conclusion: SpTR is associated with greater overall survival and PFS when compared with other glioblastoma surgeries like GTR or SubTR.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.wneu.2023.07.020 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Structural Functionally-informed Supratotal Resection: Where do we stand?
Brain Spine
August 2025
Department of Neurosurgery, King's College Hospital Foundation Trust, London, UK.
Awake surgery for IDH-mutant grade 2 glioma involving the corpus callosum: long-term onco-functional results after callosectomy in 157 consecutive patients.
J Neurosurg
July 2025
Department of Neurosurgery, Gui de Chauliac Hospital, Montpellier University Medical Center, Montpellier, France.
Objective: Because low-grade glioma (LGG) frequently migrates along the white matter pathways, it may involve the corpus callosum (CC) with possible contralateral diffusion. Contrary to glioblastoma, resection of CC invaded by LGG is poorly documented. Here, a unique experience of 157 patients who underwent awake surgery (AS) for an LGG within the CC is reported to investigate the long-term onco-functional results, including return to work (RTW), after completion of callosectomy.
View Article and Find Full Text PDFBackground: Recurrence after resection is a major factor in poor prognosis for grade 2 and 3 gliomas. The effect of Supratotal Resection (STR) on recurrence timing remains debated. This meta-analysis examines overall survival (OS) and tumor progression in grade 2 and 3 gliomas after supratotal resection.
View Article and Find Full Text PDFPushing the boundaries of neurosurgical oncology: evaluating the superiority of supratotal resection over gross total resection in intraoperative MRI-guided glioma surgery.
Neurosurg Rev
February 2025
Department of Radiology, Gazi University Faculty of Medicine, Ankara, Turkey.
Using intraoperative MRI (iMRI) in glioma surgery can enhance the extent of resection (EOR) and improve survival rates for patients diagnosed with low grade gliomas (LGG) or high grade gliomas (HGG). This study focused on patients who underwent iMRI-guided surgery for LGG and HGG at our center. Our objective was to compare the patient survival time and recurrence rate between supratotal resection (SpTR) and gross total resection(GTR).
View Article and Find Full Text PDFSupratotal Resection Versus Gross Total Resection for Isocitrate Dehydrogenase-Wildtype Glioblastoma and Grade 4 Isocitrate Dehydrogenase-Mutant Astrocytoma: Meta-Analysis of Individual Patient Data.
Oper Neurosurg
November 2024
Department of Neurosurgery, University Hospital Clementino Fraga Filho, Federal University of Rio de Janeiro, Rio de Janeiro , Brazil.
Background And Objectives: IDH-wildtype glioblastoma multiforme (GBM) and grade 4 IDH-mutant astrocytoma are challenging to manage in oncology. This study explores the contrast between gross total resection (GTR) and supratotal resection (SupTR) for IDH-wildtype GBM and grade 4 IDH-mutant astrocytoma, aiming to summarize their influence on crucial clinical outcomes.
Methods: This systematic review was conducted in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines.