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Tungsten (W), as a promising plasma-facing material for fusion nuclear reactors, exhibits ductility reduction. Introducing high-density coherent nano-dispersoids into the W matrix is a highly efficient strategy to break the tradeoff of the strength-ductility performance. In this work, we performed helium (He) ion irradiation on coherent oxide-dispersoids strengthened (ODS) W to investigate the effect of coherent nanoparticle interfaces on the behavior of He bubbles. The results show that the diameter and density of He bubbles in ODS W are close to that in W at low dose of He ion irradiation. The radiation-induced hardening increment of ODS W, being 25% lower than that of pure W, suggests the involvement of the coherent interface in weakening He ion irradiation-induced hardening and emphasizes the potential of coherent nano-dispersoids in enhancing the radiation resistance of W-based materials.
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http://dx.doi.org/10.3390/ma16134613 | DOI Listing |
Med Phys
September 2025
Heidelberg Institute for Radiation Oncology (HIRO), National Center for Research in Radiation Oncology (NCRO), Heidelberg, Germany.
Background: As advanced treatment plans increasingly include optimizing both dose and linear energy transfer (LET), there is a growing demand for tools to measure LET in clinical settings. Although various detection systems have been investigated in this pursuit, the scarcity of detectors capable of providing per-ion data for a fast and streamlined verification of LET distributions remains an issue. Silicon pixel detector technology bridges this gap by enabling rapid tracking of single-ion energy deposition.
View Article and Find Full Text PDFPhys Med Biol
September 2025
Heidelberg Institute for Radiation Oncology (HIRO) and National Center for Research in Radiation Oncology (NCRO), Im Neuenheimer Feld 280, Heidelberg, Baden-Würtemberg, 69120, GERMANY.
Ion-beam radiography has been proposed as a daily on-couch imaging modality for ion-beam radiotherapy range verification. However, an ion-beam radiograph only contains 2D information since it shows a projection of the patient along the beam direction. To extract depth information of anatomical changes from 2D helium-beam radiographs, we experimentally investigated the 2.
View Article and Find Full Text PDFAppl Microbiol Biotechnol
September 2025
Applied Microbiology, Faculty of Biology and Biotechnology, Ruhr University Bochum, Bochum, Germany.
Plasma-driven biocatalysis utilizes in situ HO production by atmospheric pressure plasmas to drive HO-dependent enzymatic reactions. Having previously established plasma-driven biocatalysis using recombinant unspecific peroxygenase from Agrocybe aegerita (rAaeUPO) to produce (R)-1-phenylethanol from ethylbenzene, we here employed CypC from Bacillus subtilis 168 (synonyms: YbdT, P450BSβ), an integral enzyme of surfactin and fengycin biosynthesis. CypC naturally hydroxylates medium and long-chain carboxylic acids.
View Article and Find Full Text PDFJ Am Soc Mass Spectrom
September 2025
Clemson University, Department of Chemistry, Clemson, South Carolina 29634, United States.
Ion mobility-mass spectrometry has shown tremendous potential for improving the analysis of various subclasses of steroids. Its speed and ability to separate isobaric and isomeric species makes it ideal for biomedical, clinical, food, environmental, and antidoping analyses. But while other high-resolution ion mobility (HRIM) techniques have begun to see increased use in steroidomics, Structures for Lossless Ion Manipulations (SLIM) is a relative newcomer to the field.
View Article and Find Full Text PDFPhys Chem Chem Phys
August 2025
Department of Chemistry, Center for Innovative Technology, Vanderbilt University, Nashville, TN 37235, USA.
Cyclodextrins (CDs) are macrocyclic oligosaccharides that have the ability to form host-guest inclusion complexes due to their amphiphilic properties, thereby allowing for an increase in the solubility and bioavailability of encapsulated small molecules, such as food constituents and active pharmaceutical ingredients (APIs). While solution-phase properties of CD inclusion complexes have been extensively studied, less is known about the prevailing coordination environment of metal-CD complexes in the absence of bulk solvent. Here, we investigate the gas-phase structural implications of alkali-metal complexation with the three naturally occurring cyclodextrins (αCD, βCD, and γCD) and a suite of linear maltodextrins using structurally-selective ion mobility-mass spectrometry (IM-MS) analysis.
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