Microwave-Assisted Syntheses of Rhodamine, Rhodol, and Fluorescein Derivatives.

Chempluschem

Institut de Chimie et Biochimie Moléculaires et Supramoléculaires (ICBMS, UMR 5246), Université Claude Bernard Lyon 1, 1 Rue Victor Grignard, 69100, Villeurbanne, France.

Published: July 2023


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Article Abstract

A series of rhodol-; fluorescein- and rhodamines-based spirolactam compounds, bearing electron donor amines have been prepared. For this purpose we have redesigned the synthesis of the rhodol scaffold using 2-(2,4-dihydroxybenzoyl)benzoic acid obtaining one example rhodol methyl ester in good yields (25-30 %) Thus, one set of non-cytotoxic rhodamine-based compounds has been prepared using thermal and microwave assisted synthesis (40-78 %) and tested as high affinity ATP chemo-sensors.

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http://dx.doi.org/10.1002/cplu.202300189DOI Listing

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