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Based on the air quality data and conventional meteorological data of the Nanjing Region from January 2015 to December 2016, to analyze the characteristics of O concentration changes in the Nanjing Region, a light gradient boosting machine (LightGBM) model was established to predict O concentration. The model was compared with three machine learning methods that are commonly used in air quality prediction, including support vector machine, recurrent neural network, and random forest methods, to verify its effectiveness and feasibility. Finally, the performance of the prediction model was analyzed under different meteorological conditions. The results showed that the variation in O concentration in Nanjing had significant seasonal differences and was affected by a combination of its pre-concentration, meteorological factors, and other air pollutant concentrations. The LightGBM model predicted the ground-level O concentration in the Nanjing area more precisely to a large extent (=0.92), and the model outperformed other models in prediction accuracy and computational efficiency. In particular, the model showed a significantly higher prediction accuracy and stability than that of other models under a high-temperature condition that was more likely prone to ozone pollution. The LightGBM model was characterized by its high prediction accuracy, good stability, satisfactory generalization ability, and short operation time, which broaden its application prospect in O concentration prediction.
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http://dx.doi.org/10.13227/j.hjkx.202208095 | DOI Listing |
Immunol Res
September 2025
Department of Immunology and Allergy, Faculty of Medicine, Necmettin Erbakan University, Konya, Türkiye.
Background: Variants of uncertain significance (VUS) represent a major diagnostic challenge in the interpretation of genetic testing results, particularly in the context of inborn errors of immunity such as severe combined immunodeficiency (SCID). The inconsistency among computational prediction tools often necessitates expensive and time-consuming wet-lab analyses.
Objective: This study aimed to develop disease-specific, multi-class machine learning models using in silico scores to classify SCID-associated genetic variants and improve the interpretation of VUS.
J Safety Res
September 2025
Department of Civil Engineering, College of Engineering, Qassim University, 51452, Saudi Arabia. Electronic address:
Introduction: The recent rise in e-scooter usage has reshaped urban mobility but has also led to a significant increase in e-scooter-related injuries, raising critical safety concerns. While existing research has primarily focused on post-crash medical outcomes and general risk comparisons, substantial gaps remain in identifying specific risk factors associated with e-scooter crashes and utilizing interpretable analytical approaches.
Method: This study addresses these gaps by analyzing 2,400 e-scooter crash records from the UK STATS19 database using advanced machine learning models to predict injury severity.
Int J Antimicrob Agents
September 2025
Dalle Molle Institute for Artificial Intelligence IDSIA. USI/SUPSI, Via la Santa 1, CH-6962 Lugano-Viganello, Switzerland. Electronic address:
Cell-penetrating peptides (CPPs) are powerful vectors for the intracellular delivery of a diverse array of therapeutic molecules. Despite their potential, the rational design of CPPs remains a challenging task that often requires extensive experimental efforts and iterations. In this study, we introduce an innovative approach for the de novo design of CPPs, leveraging the strengths of machine learning (ML) and optimization algorithms.
View Article and Find Full Text PDFJ Chem Inf Model
September 2025
Department of Chemistry, Delaware State University, Dover, Delaware 19901, United States.
The calculation of the highest occupied molecular orbital-lowest unoccupied molecular orbital (HOMO-LUMO) gap for chemical molecules is computationally intensive using quantum mechanics (QM) methods, while experimental determination is often costly and time-consuming. Machine Learning (ML) offers a cost-effective and rapid alternative, enabling efficient predictions of HOMO-LUMO gap values across large data sets without the need for extensive QM computations or experiments. ML models facilitate the screening of diverse molecules, providing valuable insights into complex chemical spaces and integrating seamlessly into high-throughput workflows to prioritize candidates for experimental validation.
View Article and Find Full Text PDFJ Cataract Refract Surg
July 2025
Department of Ophthalmology, West China Hospital of Sichuan University, Chengdu City, Sichuan Province, China.
Purpose: To develop and validate a multimodal deep-learning model for predicting postoperative vault height and selecting implantable collamer lens (ICL) sizes using Anterior Segment Optical Coherence Tomography (AS-OCT) and Ultrasound Biomicroscope (UBM) images combined with clinical features.
Setting: West China Hospital of Sichuan University, China.
Design: Deep-learning study.